Mechanisms for flow-enhanced cell adhesion.

@article{citeulike:2706347, abstract = {Cell adhesion is mediated by specific receptor-ligand bonds. In several biological systems, increasing flow has been observed to enhance cell adhesion despite the increasing dislodging fluid shear forces. Flow-enhanced cell adhesion includes several aspects: flow augments the initial tethering of flowing cells to a stationary surface, slows the velocity and increases the regularity of rolling cells, and increases the number of rollingly adherent cells. Mechanisms for this intriguing phenomenon may include transport-dependent acceleration of bond formation and force-dependent deceleration of bond dissociation. The former includes three distinct transport modes: sliding of cell bottom on the surface, Brownian motion of the cell, and rotational diffusion of the interacting molecules. The latter involves a recently demonstrated counterintuitive behavior called catch bonds where force prolongs rather than shortens the lifetimes of receptor-ligand bonds. In this article, we summarize our recently published data that used dimensional analysis and mutational analysis to elucidate the above mechanisms for flow-enhanced leukocyte adhesion mediated by L-selectin-ligand interactions.}, address = {Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta GA 30332, USA. cheng.zhu@bme.gatech.edu}, author = {Zhu, C. and Yago, T. and Lou, J. and Zarnitsyna, V. I. and McEver, R. P. }, citeulike-article-id = {2706347}, doi = {10.1007/s10439-008-9464-5}, issn = {1521-6047}, journal = {Annals of biomedical engineering}, keywords = {cell-adhesion, force-probe-md, mechanotransduction}, month = {April}, number = {4}, pages = {604--621}, posted-at = {2008-04-23 08:34:09}, priority = {3}, title = {Mechanisms for flow-enhanced cell adhesion.}, url = {http://dx.doi.org/10.1007/s10439-008-9464-5}, volume = {36}, year = {2008} }

TY - JOUR ID - citeulike:2706347 L3 - citeulike-article-id:2706347 TI - Mechanisms for flow-enhanced cell adhesion. JF - Annals of biomedical engineering VL - 36 IS - 4 SP - 604 EP - 621 AD - Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta GA 30332, USA. cheng.zhu@bme.gatech.edu SN - 1521-6047 N2 - Cell adhesion is mediated by specific receptor-ligand bonds. In several biological systems, increasing flow has been observed to enhance cell adhesion despite the increasing dislodging fluid shear forces. Flow-enhanced cell adhesion includes several aspects: flow augments the initial tethering of flowing cells to a stationary surface, slows the velocity and increases the regularity of rolling cells, and increases the number of rollingly adherent cells. Mechanisms for this intriguing phenomenon may include transport-dependent acceleration of bond formation and force-dependent deceleration of bond dissociation. The former includes three distinct transport modes: sliding of cell bottom on the surface, Brownian motion of the cell, and rotational diffusion of the interacting molecules. The latter involves a recently demonstrated counterintuitive behavior called catch bonds where force prolongs rather than shortens the lifetimes of receptor-ligand bonds. In this article, we summarize our recently published data that used dimensional analysis and mutational analysis to elucidate the above mechanisms for flow-enhanced leukocyte adhesion mediated by L-selectin-ligand interactions. KW - cell-adhesion KW - force-probe-md KW - mechanotransduction AU - Zhu, C AU - Yago, T AU - Lou, J AU - Zarnitsyna, VI AU - McEver, RP PY - 2008/04// UR - http://dx.doi.org/10.1007/s10439-008-9464-5 ER -