Adhesion signaling - crosstalk between integrins, Src and Rho. Export

@article{citeulike:5005814, abstract = {Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.}, author = {Huveneers, Stephan and Danen, Erik H.}, citeulike-article-id = {5005814}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/jcs.039446}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19339545}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19339545}, day = {15}, doi = {10.1242/jcs.039446}, issn = {0021-9533}, journal = {Journal of cell science}, keywords = {integrin, signaling}, month = {April}, number = {Pt 8}, pages = {1059--1069}, posted-at = {2009-11-12 01:55:14}, priority = {2}, title = {Adhesion signaling - crosstalk between integrins, Src and Rho.}, url = {http://dx.doi.org/10.1242/jcs.039446}, volume = {122}, year = {2009} }

TY - JOUR ID - citeulike:5005814 L3 - citeulike-article-id:5005814 N2 - Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction. IS - Pt 8 JF - Journal of cell science SN - 0021-9533 EP - 1069 TI - Adhesion signaling - crosstalk between integrins, Src and Rho. VL - 122 SP - 1059 KW - integrin KW - signaling AU - Huveneers, Stephan AU - Danen, Erik PY - 2009/04/15/ UR - http://dx.doi.org/10.1242/jcs.039446 ER -