Novel patterns of genome rearrangement and their association with survival in breast cancer. Export

@article{citeulike:1133651, abstract = {Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of approximately 50 kb. We have used this technique to examine 243 breast tumors from two separate studies for which detailed clinical data were available. The very high resolution of this technology has enabled us to identify three characteristic patterns of genomic copy number variation in diploid tumors and to measure correlations with patient survival. One of these patterns is characterized by multiple closely spaced amplicons, or "firestorms," limited to single chromosome arms. These multiple amplifications are highly correlated with aggressive disease and poor survival even when the rest of the genome is relatively quiet. Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Based on this sample, we generate the working hypothesis that copy number profiling might provide information useful in making clinical decisions, especially regarding the use or not of systemic therapies (hormonal therapy, chemotherapy), in the management of operable primary breast cancer with ostensibly good prognosis, for example, small, node-negative, hormone-receptor-positive diploid cases.}, address = {Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. hicks@cshl.edu}, author = {Hicks, J. and Krasnitz, A. and Lakshmi, B. and Navin, N. E. and Riggs, M. and Leibu, E. and Esposito, D. and Alexander, J. and Troge, J. and Grubor, V. and Yoon, S. and Wigler, M. and Ye, K. and B{\o}rresen-Dale, A. L. and Naume, B. and Schlicting, E. and Norton, L. and H\"{a}gerstr\"{o}m, T. and Skoog, L. and Auer, G. and M\r{a}n\'{e}r, S. and Lundin, P. and Zetterberg, A.}, citeulike-article-id = {1133651}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.5460106}, citeulike-linkout-1 = {http://www.genome.org/cgi/content/abstract/16/12/1465}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17142309}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17142309}, doi = {10.1101/gr.5460106}, issn = {1088-9051}, journal = {Genome Res}, keywords = {acgh, breast, cancer, firestorm}, month = {December}, number = {12}, pages = {1465--1479}, posted-at = {2008-06-26 22:30:49}, priority = {0}, title = {Novel patterns of genome rearrangement and their association with survival in breast cancer.}, url = {http://dx.doi.org/10.1101/gr.5460106}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:1133651 L3 - citeulike-article-id:1133651 N2 - Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of approximately 50 kb. We have used this technique to examine 243 breast tumors from two separate studies for which detailed clinical data were available. The very high resolution of this technology has enabled us to identify three characteristic patterns of genomic copy number variation in diploid tumors and to measure correlations with patient survival. One of these patterns is characterized by multiple closely spaced amplicons, or "firestorms," limited to single chromosome arms. These multiple amplifications are highly correlated with aggressive disease and poor survival even when the rest of the genome is relatively quiet. Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Based on this sample, we generate the working hypothesis that copy number profiling might provide information useful in making clinical decisions, especially regarding the use or not of systemic therapies (hormonal therapy, chemotherapy), in the management of operable primary breast cancer with ostensibly good prognosis, for example, small, node-negative, hormone-receptor-positive diploid cases. IS - 12 JF - Genome Res SN - 1088-9051 AD - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. hicks@cshl.edu EP - 1479 TI - Novel patterns of genome rearrangement and their association with survival in breast cancer. VL - 16 SP - 1465 KW - acgh KW - breast KW - cancer KW - firestorm AU - Hicks, J AU - Krasnitz, A AU - Lakshmi, B AU - Navin, NE AU - Riggs, M AU - Leibu, E AU - Esposito, D AU - Alexander, J AU - Troge, J AU - Grubor, V AU - Yoon, S AU - Wigler, M AU - Ye, K AU - Børresen-Dale, AL AU - Naume, B AU - Schlicting, E AU - Norton, L AU - Hägerström, T AU - Skoog, L AU - Auer, G AU - Månér, S AU - Lundin, P AU - Zetterberg, A PY - 2006/12// UR - http://dx.doi.org/10.1101/gr.5460106 ER -