Aging and Immortality in a Cell Proliferation Model Export

@article{citeulike:3814928, abstract = {We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres become shorter than a critical length. In addition to this systematic shortening, exchange of telomere DNA between the two daughter cells can occur at each cell division. We map this telomere dynamics onto a biased branching diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. As the relative effects of telomere shortening and cell division are varied, there is a phase transition between finite lifetime and infinite proliferation of the cell population. Using simple first-passage ideas, we quantify the nature of this transition.}, archivePrefix = {arXiv}, author = {Antal, T. and Blagoev, K. B. and Trugman, S. A. and Redner, S.}, citeulike-article-id = {3814928}, citeulike-linkout-0 = {http://arxiv.org/abs/q-bio/0609040}, citeulike-linkout-1 = {http://arxiv.org/pdf/q-bio/0609040}, day = {23}, eprint = {q-bio/0609040}, keywords = {aging, cell, proliferation}, month = {Apr}, posted-at = {2008-12-20 20:40:07}, priority = {2}, title = {Aging and Immortality in a Cell Proliferation Model}, url = {http://arxiv.org/abs/q-bio/0609040}, year = {2008} }

TY - JOUR ID - citeulike:3814928 L3 - citeulike-article-id:3814928 N2 - We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres become shorter than a critical length. In addition to this systematic shortening, exchange of telomere DNA between the two daughter cells can occur at each cell division. We map this telomere dynamics onto a biased branching diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. As the relative effects of telomere shortening and cell division are varied, there is a phase transition between finite lifetime and infinite proliferation of the cell population. Using simple first-passage ideas, we quantify the nature of this transition. TI - Aging and Immortality in a Cell Proliferation Model KW - aging KW - cell KW - proliferation AU - Antal, T AU - Blagoev, KB AU - Trugman, SA AU - Redner, S PY - 2008/Apr/23/ UR - http://arxiv.org/abs/q-bio/0609040 ER -