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Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis

by: Irina Kharatishvili, Riikka Immonen, Olli Gröhn, Asla Pitkänen
Brain, Vol. 130, No. 12. (01 December 2007), pp. 3155-3168, doi:10.1093/brain/awm268  Key: citeulike:11895295

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Abstract

The need to use animal models to develop imaging markers that could be linked to electrophysiological abnormalities in epilepsy and able to predict epileptogenicity in human studies is widely acknowledged. This study aimed to investigate the value of early magnetic resonance imaging (MRI) in predicting the long-term increased seizure susceptibility in the clinically relevant model of post-traumatic epilepsy (PTE).


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