Prion diseases and the BSE crisis. Export

@article{citeulike:3658809, abstract = {Bovine spongiform encephalopathy (BSE) and human Creutzfeldt-Jakob disease (CJD) are among the most notable central nervous system degenerative disorders caused by prions. CJD may present as a sporadic, genetic, or infectious illness. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular prion protein (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content. It is thought that BSE is a result of cannibalism in which faulty industrial practices produced prion-contaminated feed for cattle. There is now considerable concern that bovine prions may have been passed to humans, resulting in a new form of CJD.}, author = {Prusiner, S. B.}, citeulike-article-id = {3658809}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9323196}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9323196}, day = {10}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {bse, diseases, prion}, month = {October}, number = {5336}, pages = {245--251}, posted-at = {2008-11-22 03:57:40}, priority = {2}, title = {Prion diseases and the BSE crisis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9323196}, volume = {278}, year = {1997} }

TY - JOUR ID - citeulike:3658809 L3 - citeulike-article-id:3658809 N2 - Bovine spongiform encephalopathy (BSE) and human Creutzfeldt-Jakob disease (CJD) are among the most notable central nervous system degenerative disorders caused by prions. CJD may present as a sporadic, genetic, or infectious illness. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular prion protein (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content. It is thought that BSE is a result of cannibalism in which faulty industrial practices produced prion-contaminated feed for cattle. There is now considerable concern that bovine prions may have been passed to humans, resulting in a new form of CJD. IS - 5336 JF - Science (New York, N.Y.) SN - 0036-8075 EP - 251 TI - Prion diseases and the BSE crisis. VL - 278 SP - 245 KW - bse KW - diseases KW - prion AU - Prusiner, SB PY - 1997/10/10/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9323196 ER -