Novel proteinaceous infectious particles cause scrapie. Export

@article{citeulike:735113, abstract = {After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats. Six lines of evidence including sensitivity to proteases demonstrate that this agent contains a protein that is required for infectivity. Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation. The agent shows heterogeneity with respect to size, apparently a result of its hydrophobicity; the smallest form may have a molecular weight of 50,000 or less. Because the novel properties of the scrapie agent distinguish it from viruses, plasmids, and viroids, a new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids. Knowledge of the scrapie agent structure may have significance for understanding the causes of several degenerative diseases.}, author = {Prusiner, S. B.}, citeulike-article-id = {735113}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/6801762}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=6801762}, day = {9}, issn = {0036-8075}, journal = {Science}, keywords = {prion, scrapie}, month = {April}, number = {4542}, pages = {136--144}, posted-at = {2008-11-22 04:07:14}, priority = {2}, title = {Novel proteinaceous infectious particles cause scrapie.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/6801762}, volume = {216}, year = {1982} }

TY - JOUR ID - citeulike:735113 L3 - citeulike-article-id:735113 N2 - After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats. Six lines of evidence including sensitivity to proteases demonstrate that this agent contains a protein that is required for infectivity. Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation. The agent shows heterogeneity with respect to size, apparently a result of its hydrophobicity; the smallest form may have a molecular weight of 50,000 or less. Because the novel properties of the scrapie agent distinguish it from viruses, plasmids, and viroids, a new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids. Knowledge of the scrapie agent structure may have significance for understanding the causes of several degenerative diseases. IS - 4542 JF - Science SN - 0036-8075 EP - 144 TI - Novel proteinaceous infectious particles cause scrapie. VL - 216 SP - 136 KW - prion KW - scrapie AU - Prusiner, SB PY - 1982/04/09/ UR - http://view.ncbi.nlm.nih.gov/pubmed/6801762 ER -