Experimental advances in the characterization of metazoan gene regulatory networks Export

@article{citeulike:4222235, abstract = {Gene regulatory networks (GRNs) play a vital role in metazoan development and function, and deregulation of these networks is often implicated in disease. GRNs depict the dynamic interactions between genomic and regulatory state components. The genomic components comprise genes and their associated cis-regulatory elements. The regulatory state components consist primarily of transcriptional complexes that bind the latter elements. With the availability of complete genome sequences, several approaches have recently been developed which promise to significantly enhance our ability to identify either the genomic or regulatory state components, or the interactions between these two. In this review, I provide an in-depth overview of these approaches and detail how each contributes to a more comprehensive understanding of GRN composition and function. 10.1093/bfgp/elp001}, author = {Deplancke, Bart}, booktitle = {Brief Funct Genomic Proteomic}, citeulike-article-id = {4222235}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bfgp/elp001}, citeulike-linkout-1 = {http://bfgp.oxfordjournals.org/content/8/1/12.abstract}, citeulike-linkout-2 = {http://bfgp.oxfordjournals.org/content/8/1/12.full.pdf}, citeulike-linkout-3 = {http://bfgp.oxfordjournals.org/cgi/content/abstract/8/1/12}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19324929}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19324929}, day = {1}, doi = {10.1093/bfgp/elp001}, journal = {Brief Funct Genomic Proteomic}, keywords = {networks, regulatory}, month = {January}, number = {1}, pages = {12--27}, posted-at = {2009-11-02 21:41:11}, priority = {2}, title = {Experimental advances in the characterization of metazoan gene regulatory networks}, url = {http://dx.doi.org/10.1093/bfgp/elp001}, volume = {8}, year = {2009} }

TY - JOUR ID - citeulike:4222235 L3 - citeulike-article-id:4222235 N2 - Gene regulatory networks (GRNs) play a vital role in metazoan development and function, and deregulation of these networks is often implicated in disease. GRNs depict the dynamic interactions between genomic and regulatory state components. The genomic components comprise genes and their associated cis-regulatory elements. The regulatory state components consist primarily of transcriptional complexes that bind the latter elements. With the availability of complete genome sequences, several approaches have recently been developed which promise to significantly enhance our ability to identify either the genomic or regulatory state components, or the interactions between these two. In this review, I provide an in-depth overview of these approaches and detail how each contributes to a more comprehensive understanding of GRN composition and function. 10.1093/bfgp/elp001 IS - 1 JF - Brief Funct Genomic Proteomic EP - 27 TI - Experimental advances in the characterization of metazoan gene regulatory networks VL - 8 T2 - Brief Funct Genomic Proteomic SP - 12 KW - networks KW - regulatory AU - Deplancke, Bart PY - 2009/01/01/ UR - http://dx.doi.org/10.1093/bfgp/elp001 ER -