The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis Export

@article{citeulike:2458704, abstract = {BACKGROUND: T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80\% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20\% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. OBJECTIVES: To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. METHODS: Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. RESULTS: A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. CONCLUSIONS: UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.}, author = {Sigmundsdottir, H. and Gudjonsson, J. E. and Valdimarsson, H.}, citeulike-article-id = {2458704}, citeulike-linkout-0 = {http://dx.doi.org/10.1046/j.1365-2133.2003.05318.x}, citeulike-linkout-1 = {http://hdl.handle.net/2336/15442}, doi = {10.1046/j.1365-2133.2003.05318.x}, journal = {Br}, keywords = {openrep-test}, pages = {996--1000}, posted-at = {2008-03-02 23:28:57}, priority = {2}, title = {The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis}, url = {http://dx.doi.org/10.1046/j.1365-2133.2003.05318.x}, volume = {148}, year = {2003} }

TY - JOUR ID - citeulike:2458704 L3 - citeulike-article-id:2458704 N2 - BACKGROUND: T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. OBJECTIVES: To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. METHODS: Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. RESULTS: A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. CONCLUSIONS: UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis. JF - Br EP - 1000 TI - The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis VL - 148 SP - 996 KW - openrep-test AU - Sigmundsdottir, H AU - Gudjonsson, JE AU - Valdimarsson, H PY - 2003/// UR - http://dx.doi.org/10.1046/j.1365-2133.2003.05318.x ER -