EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Export

@article{citeulike:3132876, abstract = {We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are expressed in countergradients in retina and SC. Developmental analyses reveal that retinal axons lack D-V ordering along the L-M axis, but directionally extend branches along it to establish ordered arbors. Directed branch extension is disrupted in EphB2; EphB3-deficient mice resulting in lateral ectopic arbors. Mice with kinase-inactive EphB2 have similar D-V mapping defects indicating that forward signaling dominates over reverse signaling. Our data suggest that branches of EphB expressing axons are attracted medially by ephrin-B1, and provide molecular mechanisms for D-V mapping in visual centers.}, address = {Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA 92037, USA.}, author = {Hindges, R. and McLaughlin, T. and Genoud, N. and Henkemeyer, M. and O'Leary, D. D.}, citeulike-article-id = {3132876}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12165470}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12165470}, day = {1}, issn = {0896-6273}, journal = {Neuron}, keywords = {author-test}, month = {August}, number = {3}, pages = {475--487}, posted-at = {2008-09-04 18:29:51}, priority = {2}, title = {EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12165470}, volume = {35}, year = {2002} }

TY - JOUR ID - citeulike:3132876 L3 - citeulike-article-id:3132876 N2 - We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are expressed in countergradients in retina and SC. Developmental analyses reveal that retinal axons lack D-V ordering along the L-M axis, but directionally extend branches along it to establish ordered arbors. Directed branch extension is disrupted in EphB2; EphB3-deficient mice resulting in lateral ectopic arbors. Mice with kinase-inactive EphB2 have similar D-V mapping defects indicating that forward signaling dominates over reverse signaling. Our data suggest that branches of EphB expressing axons are attracted medially by ephrin-B1, and provide molecular mechanisms for D-V mapping in visual centers. IS - 3 JF - Neuron SN - 0896-6273 AD - Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, 92037, La Jolla, CA 92037, USA. EP - 487 TI - EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. VL - 35 SP - 475 KW - author-test AU - Hindges, R AU - McLaughlin, T AU - Genoud, N AU - Henkemeyer, M AU - O'Leary, DD PY - 2002/08/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12165470 ER -