Drosophila mojoless, a Retroposed GSK-3, Has Functionally Diverged to Acquire an Essential Role in Male Fertility Export

@article{citeulike:1144849, abstract = {Retroposition is increasingly recognized as an important mechanism for the acquisition of new genes. We show that a glycogen synthase kinase-3 gene, shaggy (sgg), retroposed at least 50 MYA in the Drosophila genus to generate a new gene, mojoless (mjl). We have extensively analyzed the function of mjl and examined its functional divergence from the parental gene sgg in Drosophila melanogaster. Unlike Sgg, which is expressed in many tissues of both sexes, Mjl is expressed specifically in the male germ line, where it is required for male germ line survival. Our analysis indicates that mjl has acquired a specific function in the maintenance of male germ line viability. However, it has not completely lost its ancestral biochemical function and can partially compensate for loss of the parental gene sgg when ectopically expressed in somatic cells. We postulate that mjl has undergone functional diversification and is now under stabilizing selection in the Drosophila genus. 10.1093/molbev/msl201}, author = {Kalamegham, Rasika and Sturgill, David and Siegfried, Esther and Oliver, Brian}, citeulike-article-id = {1144849}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/molbev/msl201}, citeulike-linkout-1 = {http://mbe.oxfordjournals.org/cgi/content/abstract/24/3/732}, citeulike-linkout-2 = {http://www.ingentaconnect.com/content/oup/molbev/2007/00000024/00000003/art00732}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/17179138}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=17179138}, day = {1}, doi = {10.1093/molbev/msl201}, issn = {0737-4038}, journal = {Mol Biol Evol}, keywords = {drosophila, positive\_selection, retrogenes}, month = {March}, number = {3}, pages = {732--742}, posted-at = {2009-09-14 14:44:11}, priority = {2}, publisher = {Oxford University Press}, title = {Drosophila mojoless, a Retroposed GSK-3, Has Functionally Diverged to Acquire an Essential Role in Male Fertility}, url = {http://dx.doi.org/10.1093/molbev/msl201}, volume = {24}, year = {2007} }

TY - JOUR ID - citeulike:1144849 L3 - citeulike-article-id:1144849 N2 - Retroposition is increasingly recognized as an important mechanism for the acquisition of new genes. We show that a glycogen synthase kinase-3 gene, shaggy (sgg), retroposed at least 50 MYA in the Drosophila genus to generate a new gene, mojoless (mjl). We have extensively analyzed the function of mjl and examined its functional divergence from the parental gene sgg in Drosophila melanogaster. Unlike Sgg, which is expressed in many tissues of both sexes, Mjl is expressed specifically in the male germ line, where it is required for male germ line survival. Our analysis indicates that mjl has acquired a specific function in the maintenance of male germ line viability. However, it has not completely lost its ancestral biochemical function and can partially compensate for loss of the parental gene sgg when ectopically expressed in somatic cells. We postulate that mjl has undergone functional diversification and is now under stabilizing selection in the Drosophila genus. 10.1093/molbev/msl201 IS - 3 JF - Mol Biol Evol SN - 0737-4038 EP - 742 TI - Drosophila mojoless, a Retroposed GSK-3, Has Functionally Diverged to Acquire an Essential Role in Male Fertility PB - Oxford University Press VL - 24 SP - 732 KW - drosophila KW - positive_selection KW - retrogenes AU - Kalamegham, Rasika AU - Sturgill, David AU - Siegfried, Esther AU - Oliver, Brian PY - 2007/03/01/ UR - http://dx.doi.org/10.1093/molbev/msl201 ER -