A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes Export

@article{citeulike:6074775, abstract = {We have identified 52 novel human cadherin-like genes organized into three closely linked clusters. Comparison of the genomic DNA sequences with those of representative cDNAs reveals a striking genomic organization similar to that of immunoglobulin and T cell receptor gene clusters. The N-terminal extracellular and transmembrane domains of each cadherin protein are encoded by a distinct and unusually large exon. These exons are organized in a tandem array. By contrast, the C-terminal cytoplasmic domain of each protein is identical and is encoded by three small exons located downstream from the cluster of N-terminal exons. This unusual organization has interesting implications regarding the molecular code required to establish complex networks of neuronal connections in the brain and the mechanisms of cell-specific cadherin-like gene expression.}, author = {Wu, Q. and Maniatis, T.}, citeulike-article-id = {6074775}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0092-8674(00)80789-8}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867400807898}, day = {11}, doi = {10.1016/S0092-8674(00)80789-8}, issn = {00928674}, journal = {Cell}, keywords = {cluster, evolution, identification, protocadherin}, month = {June}, number = {6}, pages = {779--790}, posted-at = {2009-11-05 15:42:58}, priority = {2}, title = {A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes}, url = {http://dx.doi.org/10.1016/S0092-8674(00)80789-8}, volume = {97}, year = {1999} }

TY - JOUR ID - citeulike:6074775 L3 - citeulike-article-id:6074775 N2 - We have identified 52 novel human cadherin-like genes organized into three closely linked clusters. Comparison of the genomic DNA sequences with those of representative cDNAs reveals a striking genomic organization similar to that of immunoglobulin and T cell receptor gene clusters. The N-terminal extracellular and transmembrane domains of each cadherin protein are encoded by a distinct and unusually large exon. These exons are organized in a tandem array. By contrast, the C-terminal cytoplasmic domain of each protein is identical and is encoded by three small exons located downstream from the cluster of N-terminal exons. This unusual organization has interesting implications regarding the molecular code required to establish complex networks of neuronal connections in the brain and the mechanisms of cell-specific cadherin-like gene expression. IS - 6 JF - Cell SN - 00928674 EP - 790 TI - A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes VL - 97 SP - 779 KW - cluster KW - evolution KW - identification KW - protocadherin AU - Wu, Q AU - Maniatis, T PY - 1999/06/11/ UR - http://dx.doi.org/10.1016/S0092-8674(00)80789-8 ER -