Inferring Nonneutral Evolution from Human-Chimp-Mouse Orthologous Gene Trios Export

@article{citeulike:669134, abstract = {Even though human and chimpanzee gene sequences are nearly 99\% identical, sequence comparisons can nevertheless be highly informative in identifying biologically important changes that have occurred since our ancestral lineages diverged. We analyzed alignments of 7645 chimpanzee gene sequences to their human and mouse orthologs. These three-species sequence alignments allowed us to identify genes undergoing natural selection along the human and chimp lineage by fitting models that include parameters specifying rates of synonymous and nonsynonymous nucleotide substitution. This evolutionary approach revealed an informative set of genes with significantly different patterns of substitution on the human lineage compared with the chimpanzee and mouse lineages. Partitions of genes into inferred biological classes identified accelerated evolution in several functional classes, including olfaction and nuclear transport. In addition to suggesting adaptive physiological differences between chimps and humans, human-accelerated genes are significantly more likely to underlie major known Mendelian disorders. 10.1126/science.1088821}, address = {Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.}, author = {Clark, Andrew G. and Glanowski, Stephen and Nielsen, Rasmus and Thomas, Paul D. and Kejariwal, Anish and Todd, Melissa A. and Tanenbaum, David M. and Civello, Daniel and Lu, Fu and Murphy, Brian and Ferriera, Steve and Wang, Gary and Zheng, Xianqgun and White, Thomas J. and Sninsky, John J. and Adams, Mark D. and Cargill, Michele}, citeulike-article-id = {669134}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1088821}, citeulike-linkout-1 = {http://www.sciencemag.org/content/302/5652/1960.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/302/5652/1960.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/302/5652/1960}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/14671302}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=14671302}, day = {12}, doi = {10.1126/science.1088821}, issn = {1095-9203}, journal = {Science}, keywords = {chimpanzee, evolution, gimelbrant, olfactory}, month = {December}, number = {5652}, pages = {1960--1963}, posted-at = {2009-11-09 15:02:12}, priority = {2}, title = {Inferring Nonneutral Evolution from Human-Chimp-Mouse Orthologous Gene Trios}, url = {http://dx.doi.org/10.1126/science.1088821}, volume = {302}, year = {2003} }

TY - JOUR ID - citeulike:669134 L3 - citeulike-article-id:669134 N2 - Even though human and chimpanzee gene sequences are nearly 99% identical, sequence comparisons can nevertheless be highly informative in identifying biologically important changes that have occurred since our ancestral lineages diverged. We analyzed alignments of 7645 chimpanzee gene sequences to their human and mouse orthologs. These three-species sequence alignments allowed us to identify genes undergoing natural selection along the human and chimp lineage by fitting models that include parameters specifying rates of synonymous and nonsynonymous nucleotide substitution. This evolutionary approach revealed an informative set of genes with significantly different patterns of substitution on the human lineage compared with the chimpanzee and mouse lineages. Partitions of genes into inferred biological classes identified accelerated evolution in several functional classes, including olfaction and nuclear transport. In addition to suggesting adaptive physiological differences between chimps and humans, human-accelerated genes are significantly more likely to underlie major known Mendelian disorders. 10.1126/science.1088821 IS - 5652 JF - Science SN - 1095-9203 AD - Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. EP - 1963 TI - Inferring Nonneutral Evolution from Human-Chimp-Mouse Orthologous Gene Trios VL - 302 SP - 1960 KW - chimpanzee KW - evolution KW - gimelbrant KW - olfactory AU - Clark, Andrew AU - Glanowski, Stephen AU - Nielsen, Rasmus AU - Thomas, Paul AU - Kejariwal, Anish AU - Todd, Melissa AU - Tanenbaum, David AU - Civello, Daniel AU - Lu, Fu AU - Murphy, Brian AU - Ferriera, Steve AU - Wang, Gary AU - Zheng, Xianqgun AU - White, Thomas AU - Sninsky, John AU - Adams, Mark AU - Cargill, Michele PY - 2003/12/12/ UR - http://dx.doi.org/10.1126/science.1088821 ER -