Prospective Memory in HIV-1 Infection Export

@article{citeulike:4994317, abstract = {The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-\`{a}-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time- and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis.}, author = {Carey, Catherine L. and Woods, Steven P. and Rippeth, Julie D. and Heaton, Robert K. and Grant, Igor and Group, The H. I. V.}, citeulike-article-id = {4994317}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/13803390590949494}, doi = {10.1080/13803390590949494}, journal = {Journal of Clinical and Experimental Neuropsychology}, keywords = {circuits, hiv, neuropathogenesis, prefronto-striatal-thalamo-cortical}, number = {4}, pages = {536--548}, posted-at = {2009-06-28 04:26:37}, priority = {5}, publisher = {Psychology Press}, title = {Prospective Memory in HIV-1 Infection}, url = {http://dx.doi.org/10.1080/13803390590949494}, volume = {28}, year = {2006} }

TY - JOUR ID - citeulike:4994317 L3 - citeulike-article-id:4994317 N2 - The cognitive deficits associated with HIV-1 infection are thought to primarily reflect neuropathophysiology within the fronto-striato-thalamo-cortical circuits. Prospective memory (ProM) is a cognitive function that is largely dependent on prefronto-striatal circuits, but has not previously been examined in an HIV-1 sample. A form of episodic memory, ProM involves the complex processes of forming, monitoring, and executing future intentions vis-à-vis ongoing distractions. The current study examined ProM in 42 participants with HIV-1 infection and 29 demographically similar seronegative healthy comparison (HC) subjects. The HIV-1 sample demonstrated deficits in time- and event-based ProM, as well as more frequent 24-hour delay ProM failures and task substitution errors relative to the HC group. In contrast, there were no significant differences in recognition performance, indicating that the HIV-1 group was able to accurately retain and recognize the ProM intention when retrieval demands were minimized. Secondary analyses revealed that ProM performance correlated with validated clinical measures of executive functions, episodic memory (free recall), and verbal working memory, but not with tests of semantic memory, retention, or recognition discrimination. Taken together, these findings indicate that HIV-1 infection is associated with ProM impairment that is primarily driven by a breakdown in the strategic (i.e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis. IS - 4 JF - Journal of Clinical and Experimental Neuropsychology EP - 548 TI - Prospective Memory in HIV-1 Infection PB - Psychology Press VL - 28 SP - 536 KW - circuits KW - hiv KW - neuropathogenesis KW - prefronto-striatal-thalamo-cortical AU - Carey, Catherine AU - Woods, Steven AU - Rippeth, Julie AU - Heaton, Robert AU - Grant, Igor AU - Group, The PY - 2006/// UR - http://dx.doi.org/10.1080/13803390590949494 ER -