Transcriptional regulatory code of a eukaryotic genome Export

@article{citeulike:466068, abstract = {DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to specific sequences to induce or repress gene expression1. Comparative genomics has recently been used to identify potential cis-regulatory sequences within the yeast genome on the basis of phylogenetic conservation2, 3, 4, 5, 6, but this information alone does not reveal if or when transcriptional regulators occupy these binding sites. We have constructed an initial map of yeast's transcriptional regulatory code by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species. The organization of regulatory elements in promoters and the environment-dependent use of these elements by regulators are discussed. We find that environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators.}, author = {Harbison, Christopher T. and Gordon, D. Benjamin and Lee, Tong I. and Rinaldi, Nicola J. and Macisaac, Kenzie D. and Danford, Timothy W. and Hannett, Nancy M. and Tagne, Jean-Bosco and Reynolds, David B. and Yoo, Jane and Jennings, Ezra G. and Zeitlinger, Julia and Pokholok, Dmitry K. and Kellis, Manolis and Rolfe, P. Alex and Takusagawa, Ken T. and Lander, Eric S. and Gifford, David K. and Fraenkel, Ernest and Young, Richard A.}, citeulike-article-id = {466068}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature02800}, citeulike-linkout-1 = {http://adsabs.harvard.edu/cgi-bin/nph-bib_query?bibcode=2004Natur.431...99H}, citeulike-linkout-2 = {http://dx.doi.org/10.1038/nature02800}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/15343339}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=15343339}, day = {02}, doi = {10.1038/nature02800}, issn = {0028-0836}, journal = {Nature}, keywords = {molecular\_biology}, month = {September}, number = {7004}, pages = {99--104}, posted-at = {2006-05-22 17:42:18}, priority = {2}, publisher = {Nature Publishing Group}, title = {Transcriptional regulatory code of a eukaryotic genome}, url = {http://dx.doi.org/10.1038/nature02800}, volume = {431}, year = {2004} }

TY - JOUR ID - citeulike:466068 L3 - citeulike-article-id:466068 N2 - DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to specific sequences to induce or repress gene expression1. Comparative genomics has recently been used to identify potential cis-regulatory sequences within the yeast genome on the basis of phylogenetic conservation2, 3, 4, 5, 6, but this information alone does not reveal if or when transcriptional regulators occupy these binding sites. We have constructed an initial map of yeast's transcriptional regulatory code by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species. The organization of regulatory elements in promoters and the environment-dependent use of these elements by regulators are discussed. We find that environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators. IS - 7004 JF - Nature SN - 0028-0836 EP - 104 TI - Transcriptional regulatory code of a eukaryotic genome PB - Nature Publishing Group VL - 431 SP - 99 KW - molecular_biology AU - Harbison, Christopher AU - Gordon, Benjamin AU - Lee, Tong AU - Rinaldi, Nicola AU - Macisaac, Kenzie AU - Danford, Timothy AU - Hannett, Nancy AU - Tagne, Jean-Bosco AU - Reynolds, David AU - Yoo, Jane AU - Jennings, Ezra AU - Zeitlinger, Julia AU - Pokholok, Dmitry AU - Kellis, Manolis AU - Rolfe, Alex AU - Takusagawa, Ken AU - Lander, Eric AU - Gifford, David AU - Fraenkel, Ernest AU - Young, Richard PY - 2004/09/02/ UR - http://dx.doi.org/10.1038/nature02800 ER -