Metagenomic Analysis of the Human Distal Gut Microbiome Export

@article{citeulike:681624, abstract = {The human intestinal microbiota is composed of 1013 to 1014 microorganisms whose collective genome ("microbiome") contains at least 100 times as many genes as our own genome. We analyzed [\~{}]78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction-amplified 16S ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults. Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes. Our microbiome has significantly enriched metabolism of glycans, amino acids, and xenobiotics; methanogenesis; and 2-methyl-D-erythritol 4-phosphate pathway-mediated biosynthesis of vitamins and isoprenoids. Thus, humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes. 10.1126/science.1124234}, author = {Gill, Steven R. and Pop, Mihai and DeBoy, Robert T. and Eckburg, Paul B. and Turnbaugh, Peter J. and Samuel, Buck S. and Gordon, Jeffrey I. and Relman, David A. and Fraser-Liggett, Claire M. and Nelson, Karen E.}, citeulike-article-id = {681624}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1124234}, citeulike-linkout-1 = {http://www.sciencemag.org/content/312/5778/1355.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/312/5778/1355.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/312/5778/1355}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/16741115}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=16741115}, day = {2}, doi = {10.1126/science.1124234}, journal = {Science}, keywords = {gut-microflora}, month = {June}, number = {5778}, pages = {1355--1359}, posted-at = {2006-06-04 20:09:19}, priority = {2}, title = {Metagenomic Analysis of the Human Distal Gut Microbiome}, url = {http://dx.doi.org/10.1126/science.1124234}, volume = {312}, year = {2006} }

TY - JOUR ID - citeulike:681624 L3 - citeulike-article-id:681624 N2 - The human intestinal microbiota is composed of 1013 to 1014 microorganisms whose collective genome ("microbiome") contains at least 100 times as many genes as our own genome. We analyzed [~]78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction-amplified 16S ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults. Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes. Our microbiome has significantly enriched metabolism of glycans, amino acids, and xenobiotics; methanogenesis; and 2-methyl-D-erythritol 4-phosphate pathway-mediated biosynthesis of vitamins and isoprenoids. Thus, humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes. 10.1126/science.1124234 IS - 5778 JF - Science EP - 1359 TI - Metagenomic Analysis of the Human Distal Gut Microbiome VL - 312 SP - 1355 KW - gut-microflora AU - Gill, Steven AU - Pop, Mihai AU - DeBoy, Robert AU - Eckburg, Paul AU - Turnbaugh, Peter AU - Samuel, Buck AU - Gordon, Jeffrey AU - Relman, David AU - Fraser-Liggett, Claire AU - Nelson, Karen PY - 2006/06/02/ UR - http://dx.doi.org/10.1126/science.1124234 ER -