Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder Export

@article{citeulike:687906, abstract = {Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective. To study amygdala dysfunction, we examined neural mechanisms mediating face processing in 22 youths (mean age 14.21 {+/-} 3.11 yr) with BD and 21 controls of comparable age, gender, and IQ. Event-related functional MRI compared neural activation when attention was directed to emotional aspects of faces (hostility, subjects' fearfulness) vs. nonemotional aspects (nose width). Compared with controls, patients perceived greater hostility in neutral faces and reported more fear when viewing them. Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala and bilateral accumbens when rating their fear of the face. There were no between-group behavioral or neural differences in the nonemotional conditions. Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability. 10.1073/pnas.0603246103}, author = {Rich, Brendan A. and Vinton, Deborah T. and Roberson-Nay, Roxann and Hommer, Rebecca E. and Berghorst, Lisa H. and Mcclure, Erin B. and Fromm, Stephen J. and Pine, Daniel S. and Leibenluft, Ellen}, citeulike-article-id = {687906}, citeulike-linkout-0 = {http://www.pnas.org/cgi/content/abstract/103/23/8900}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16735472}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16735472}, day = {6}, journal = {PNAS}, keywords = {bipolar-disorder, limbic, psychology}, month = {June}, number = {23}, pages = {8900--8905}, posted-at = {2006-06-07 06:59:56}, priority = {2}, title = {Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder}, url = {http://www.pnas.org/cgi/content/abstract/103/23/8900}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:687906 L3 - citeulike-article-id:687906 N2 - Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspective. To study amygdala dysfunction, we examined neural mechanisms mediating face processing in 22 youths (mean age 14.21 {+/-} 3.11 yr) with BD and 21 controls of comparable age, gender, and IQ. Event-related functional MRI compared neural activation when attention was directed to emotional aspects of faces (hostility, subjects' fearfulness) vs. nonemotional aspects (nose width). Compared with controls, patients perceived greater hostility in neutral faces and reported more fear when viewing them. Also, compared with controls, patients had greater activation in the left amygdala, accumbens, putamen, and ventral prefrontal cortex when rating face hostility, and greater activation in the left amygdala and bilateral accumbens when rating their fear of the face. There were no between-group behavioral or neural differences in the nonemotional conditions. Results implicate deficient emotion-attention interactions in the pathophysiology of BD in youth and suggest that developmental psychobiology approaches to chronic mental illness have broad applicability. 10.1073/pnas.0603246103 IS - 23 JF - PNAS EP - 8905 TI - Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder VL - 103 SP - 8900 KW - bipolar-disorder KW - limbic KW - psychology AU - Rich, Brendan AU - Vinton, Deborah AU - Roberson-Nay, Roxann AU - Hommer, Rebecca AU - Berghorst, Lisa AU - Mcclure, Erin AU - Fromm, Stephen AU - Pine, Daniel AU - Leibenluft, Ellen PY - 2006/06/06/ UR - http://www.pnas.org/cgi/content/abstract/103/23/8900 ER -