cmor's Bayes [1 article]

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Evolutionary expansion and anatomical specialization of synapse proteome complexity

Nature Neuroscience, Vol. 11, No. 7. (08 June 2008), pp. 799-806.

by Richard D. Emes, Andrew J. Pocklington, Christopher N. G. Anderson, et al.Alex Bayes, Mark O. Collins, Catherine A. Vickers, Mike D. R. Croning, Bilal R. Malik, Jyoti S. Choudhary, J. Douglas Armstrong, Seth G. N. Grant

posted to no-tag by cmor on 2009-12-22 10:53:22

along with 6 people and 1 group mordiano bhengeveld gurprit_raunu daforerog sekulerlab balicea VisionLab

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Abstract

Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs) that underlie learning and memory. PSD and MASC orthologs found in yeast carry out basic cellular functions to regulate protein synthesis and structural plasticity. We observed marked changes in signaling complexity at the yeast-metazoan and invertebrate-vertebrate boundaries, with an expansion ...

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cmor's Bayes [1 article]

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