Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Export

@article{citeulike:3974543, abstract = {Emk is a serine/threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics. To delineate the role of Emk in development and adult tissues, mice lacking Emk were generated by targeted gene disruption. Emk(-/-) mice displayed growth retardation and immune cell dysfunction. Although B- and T-cell development were normal, CD4(+)T cells lacking Emk exhibited a marked upregulation of the memory marker CD44/pgp-1 and produced more gamma interferon and interleukin-4 on stimulation through the T-cell receptor in vitro. In addition, B-cell responses to T-cell-dependent and -independent antigen challenge were altered in vivo. As Emk(-/-) animals aged, they developed splenomegaly, lymphadenopathy, membranoproliferative glomerulonephritis, and lymphocytic infiltrates in the lungs, parotid glands and kidneys. Taken together, these results demonstrate that the Emk protein kinase is essential for maintaining immune system homeostasis and that loss of Emk may contribute to autoimmune disease in mammals.}, author = {Hurov, J. B. and Stappenbeck, T. S. and Zmasek, C. M. and White, L. S. and Ranganath, S. H. and Russell, J. H. and Chan, A. C. and Murphy, K. M. and Piwnica-Worms, H.}, citeulike-article-id = {3974543}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/MCB.21.9.3206-3219.2001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11287624}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11287624}, doi = {10.1128/MCB.21.9.3206-3219.2001}, issn = {0270-7306}, journal = {Molecular and cellular biology}, keywords = {emk, par}, month = {May}, number = {9}, pages = {3206--3219}, posted-at = {2009-01-28 22:53:40}, priority = {2}, title = {Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase.}, url = {http://dx.doi.org/10.1128/MCB.21.9.3206-3219.2001}, volume = {21}, year = {2001} }

TY - JOUR ID - citeulike:3974543 L3 - citeulike-article-id:3974543 N2 - Emk is a serine/threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics. To delineate the role of Emk in development and adult tissues, mice lacking Emk were generated by targeted gene disruption. Emk(-/-) mice displayed growth retardation and immune cell dysfunction. Although B- and T-cell development were normal, CD4(+)T cells lacking Emk exhibited a marked upregulation of the memory marker CD44/pgp-1 and produced more gamma interferon and interleukin-4 on stimulation through the T-cell receptor in vitro. In addition, B-cell responses to T-cell-dependent and -independent antigen challenge were altered in vivo. As Emk(-/-) animals aged, they developed splenomegaly, lymphadenopathy, membranoproliferative glomerulonephritis, and lymphocytic infiltrates in the lungs, parotid glands and kidneys. Taken together, these results demonstrate that the Emk protein kinase is essential for maintaining immune system homeostasis and that loss of Emk may contribute to autoimmune disease in mammals. IS - 9 JF - Molecular and cellular biology SN - 0270-7306 EP - 3219 TI - Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. VL - 21 SP - 3206 KW - emk KW - par AU - Hurov, JB AU - Stappenbeck, TS AU - Zmasek, CM AU - White, LS AU - Ranganath, SH AU - Russell, JH AU - Chan, AC AU - Murphy, KM AU - Piwnica-Worms, H PY - 2001/05// UR - http://dx.doi.org/10.1128/MCB.21.9.3206-3219.2001 ER -