Apprehending multicellularity: Regulatory networks, genomics, and evolution Export

@article{citeulike:4885388, abstract = {The genomic revolution has provided the first glimpses of the architecture of regulatory networks. Combined with evolutionary information, the ldquonetwork viewrdquo of life processes leads to remarkable insights into how biological systems have been shaped by various forces. This understanding is critical because biological systems, including regulatory networks, are not products of engineering but of historical contingencies. In this light, we attempt a synthetic overview of the natural history of regulatory networks operating in the development and differentiation of multicellular organisms. We first introduce regulatory networks and their organizational principles as can be deduced using ideas from the graph theory. We then discuss findings from comparative genomics to illustrate the effects of lineage-specific expansions, gene-loss, and nonprotein-coding DNA on the architecture of networks. We consider the interaction between expansions of transcription factors, and cis regulatory and more general chromatin state stabilizing elements in the emergence of morphological complexity. Finally, we consider a case study of the Notch subnetwork, which is present throughout Metazoa, to examine how such a regulatory system has been pieced together in evolution from new innovations and pre-existing components that were originally functionally distinct. Birth Defects Research (Part C) 87:143-164, 2009. {\copyright} 2009 Wiley-Liss, Inc.}, address = {National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland}, author = {Aravind, L. and Anantharaman, Vivek and Venancio, Thiago M.}, citeulike-article-id = {4885388}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bdrc.20153}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19530132}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19530132}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122457392/ABSTRACT}, day = {15}, doi = {10.1002/bdrc.20153}, issn = {1542-9768}, journal = {Birth Defects Research Part C: Embryo Today: Reviews}, keywords = {multicellularity, network-evolution, regulatory\_network\_evolution}, month = {June}, number = {2}, pages = {143--164}, posted-at = {2009-10-07 18:29:27}, priority = {4}, title = {Apprehending multicellularity: Regulatory networks, genomics, and evolution}, url = {http://dx.doi.org/10.1002/bdrc.20153}, volume = {87}, year = {2009} }

TY - JOUR ID - citeulike:4885388 L3 - citeulike-article-id:4885388 N2 - The genomic revolution has provided the first glimpses of the architecture of regulatory networks. Combined with evolutionary information, the ldquonetwork viewrdquo of life processes leads to remarkable insights into how biological systems have been shaped by various forces. This understanding is critical because biological systems, including regulatory networks, are not products of engineering but of historical contingencies. In this light, we attempt a synthetic overview of the natural history of regulatory networks operating in the development and differentiation of multicellular organisms. We first introduce regulatory networks and their organizational principles as can be deduced using ideas from the graph theory. We then discuss findings from comparative genomics to illustrate the effects of lineage-specific expansions, gene-loss, and nonprotein-coding DNA on the architecture of networks. We consider the interaction between expansions of transcription factors, and cis regulatory and more general chromatin state stabilizing elements in the emergence of morphological complexity. Finally, we consider a case study of the Notch subnetwork, which is present throughout Metazoa, to examine how such a regulatory system has been pieced together in evolution from new innovations and pre-existing components that were originally functionally distinct. Birth Defects Research (Part C) 87:143-164, 2009. © 2009 Wiley-Liss, Inc. IS - 2 JF - Birth Defects Research Part C: Embryo Today: Reviews SN - 1542-9768 AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland EP - 164 TI - Apprehending multicellularity: Regulatory networks, genomics, and evolution VL - 87 SP - 143 KW - multicellularity KW - network-evolution KW - regulatory_network_evolution AU - Aravind, L AU - Anantharaman, Vivek AU - Venancio, Thiago PY - 2009/06/15/ UR - http://dx.doi.org/10.1002/bdrc.20153 ER -