Caspases and kinases in a death grip. Export

@article{citeulike:5722801, abstract = {The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can terminate prosurvival signaling or generate proapoptotic peptide fragments that help to execute the death program and facilitate packaging of the dying cells. Here, we review caspases as kinase substrates and kinases as caspase substrates and discuss how the balance between cell survival and cell death can be shifted through crosstalk between these two enzyme families.}, author = {Kurokawa, Manabu and Kornbluth, Sally}, citeulike-article-id = {5722801}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2009.08.021}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867409010381}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19737514}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19737514}, day = {4}, doi = {10.1016/j.cell.2009.08.021}, issn = {1097-4172}, journal = {Cell}, keywords = {apoptosis, caspases, kinases, review}, month = {September}, number = {5}, pages = {838--854}, posted-at = {2009-09-28 19:34:10}, priority = {2}, title = {Caspases and kinases in a death grip.}, url = {http://dx.doi.org/10.1016/j.cell.2009.08.021}, volume = {138}, year = {2009} }

TY - JOUR ID - citeulike:5722801 L3 - citeulike-article-id:5722801 N2 - The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can terminate prosurvival signaling or generate proapoptotic peptide fragments that help to execute the death program and facilitate packaging of the dying cells. Here, we review caspases as kinase substrates and kinases as caspase substrates and discuss how the balance between cell survival and cell death can be shifted through crosstalk between these two enzyme families. IS - 5 JF - Cell SN - 1097-4172 EP - 854 TI - Caspases and kinases in a death grip. VL - 138 SP - 838 KW - apoptosis KW - caspases KW - kinases KW - review AU - Kurokawa, Manabu AU - Kornbluth, Sally PY - 2009/09/04/ UR - http://dx.doi.org/10.1016/j.cell.2009.08.021 ER -