Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I. Export

@article{citeulike:5793137, abstract = {Proof that plants possess homologs of animal adhesion proteins is lacking. In this paper we describe the generation of monoclonal antibodies that interfere with cell-cell contacts in the 4-cell embryo of the multicellular alga Volvox carteri, resulting in a hole between the cells. The number of following cell divisions is reduced and the cell division pattern is altered drastically. Antibodies given at a later stage of embryogenesis specifically inhibit inversion of the embryo, a morphogenetic movement that turns the embryo inside out. Immunofluorescence microscopy localizes the antigen (Algal-CAM) at cell contact sites of the developing embryo. Algal-CAM is a protein with a three-domain structure: an N-terminal extensin-like domain characteristic for plant cell walls and two repeats with homology to fasciclin I, a cell adhesion molecule involved in the neuronal development of Drosophila. Alternatively spliced variants of Algal-CAM mRNA were detected that are produced under developmental control. Thus, Algal-CAM is the first plant homolog of animal adhesion proteins.}, author = {Huber, O. and Sumper, M.}, citeulike-article-id = {5793137}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7925267}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7925267}, day = {15}, issn = {0261-4189}, journal = {The EMBO journal}, keywords = {algae, cam, cell\_adhesion, fasciclin, volvox}, month = {September}, number = {18}, pages = {4212--4222}, posted-at = {2009-09-16 20:39:34}, priority = {2}, title = {Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7925267}, volume = {13}, year = {1994} }

TY - JOUR ID - citeulike:5793137 L3 - citeulike-article-id:5793137 N2 - Proof that plants possess homologs of animal adhesion proteins is lacking. In this paper we describe the generation of monoclonal antibodies that interfere with cell-cell contacts in the 4-cell embryo of the multicellular alga Volvox carteri, resulting in a hole between the cells. The number of following cell divisions is reduced and the cell division pattern is altered drastically. Antibodies given at a later stage of embryogenesis specifically inhibit inversion of the embryo, a morphogenetic movement that turns the embryo inside out. Immunofluorescence microscopy localizes the antigen (Algal-CAM) at cell contact sites of the developing embryo. Algal-CAM is a protein with a three-domain structure: an N-terminal extensin-like domain characteristic for plant cell walls and two repeats with homology to fasciclin I, a cell adhesion molecule involved in the neuronal development of Drosophila. Alternatively spliced variants of Algal-CAM mRNA were detected that are produced under developmental control. Thus, Algal-CAM is the first plant homolog of animal adhesion proteins. IS - 18 JF - The EMBO journal SN - 0261-4189 EP - 4222 TI - Algal-CAMs: isoforms of a cell adhesion molecule in embryos of the alga Volvox with homology to Drosophila fasciclin I. VL - 13 SP - 4212 KW - algae KW - cam KW - cell_adhesion KW - fasciclin KW - volvox AU - Huber, O AU - Sumper, M PY - 1994/09/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/7925267 ER -