Mitochondria in energy-limited states: mechanisms that blunt the signaling of cell death Export

@article{citeulike:5907905, abstract = {Cellular conditions experienced during energy-limited states - elevated calcium, shifts in cellular adenylate status, compromised mitochondrial membrane potential - are precisely those that trigger, at least in mammals, the mitochondrion to initiate opening of the permeability transition pore, to assemble additional protein release channels, and to release pro-apoptotic factors. These pro-apototic factors in turn activate initiator and executer caspases. How is activation of mitochondria-based pathways for the signaling of apoptotic and necrotic cell death avoided under conditions of hypoxia, anoxia, diapause, estivation and anhydrobiosis? Functional trade-offs in environmental tolerance may have occurred in parallel with the evolution of diversified pathways for the signaling of cell death in eukaryotic organisms. Embryos of the brine shrimp, Artemia franciscana, survive extended periods of anoxia and diapause, and evidence indicates that opening of the mitochondrial permeability transition pore and release of cytochrome c (cyt-c) do not occur. Further, caspase activation in this crustacean is not dependent on cyt-c. Its caspases display regulation by nucleotides that is consistent with `applying the brakes' to cell death during energy limitation. Unraveling the mechanisms by which organisms in extreme environments avoid cell death may suggest possible interventions during disease states and biostabilization of mammalian cells. 10.1242/jeb.000299}, author = {Hand, Steven C. and Menze, Michael A.}, citeulike-article-id = {5907905}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/jeb.000299}, citeulike-linkout-1 = {http://jeb.biologists.org/content/211/12/1829.abstract}, citeulike-linkout-2 = {http://jeb.biologists.org/content/211/12/1829.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18515712}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18515712}, day = {15}, doi = {10.1242/jeb.000299}, journal = {J Exp Biol}, keywords = {apoptosis, mitochondria}, month = {June}, number = {12}, pages = {1829--1840}, posted-at = {2009-10-08 00:03:57}, priority = {4}, title = {Mitochondria in energy-limited states: mechanisms that blunt the signaling of cell death}, url = {http://dx.doi.org/10.1242/jeb.000299}, volume = {211}, year = {2008} }

TY - JOUR ID - citeulike:5907905 L3 - citeulike-article-id:5907905 N2 - Cellular conditions experienced during energy-limited states - elevated calcium, shifts in cellular adenylate status, compromised mitochondrial membrane potential - are precisely those that trigger, at least in mammals, the mitochondrion to initiate opening of the permeability transition pore, to assemble additional protein release channels, and to release pro-apoptotic factors. These pro-apototic factors in turn activate initiator and executer caspases. How is activation of mitochondria-based pathways for the signaling of apoptotic and necrotic cell death avoided under conditions of hypoxia, anoxia, diapause, estivation and anhydrobiosis? Functional trade-offs in environmental tolerance may have occurred in parallel with the evolution of diversified pathways for the signaling of cell death in eukaryotic organisms. Embryos of the brine shrimp, Artemia franciscana, survive extended periods of anoxia and diapause, and evidence indicates that opening of the mitochondrial permeability transition pore and release of cytochrome c (cyt-c) do not occur. Further, caspase activation in this crustacean is not dependent on cyt-c. Its caspases display regulation by nucleotides that is consistent with `applying the brakes' to cell death during energy limitation. Unraveling the mechanisms by which organisms in extreme environments avoid cell death may suggest possible interventions during disease states and biostabilization of mammalian cells. 10.1242/jeb.000299 IS - 12 JF - J Exp Biol EP - 1840 TI - Mitochondria in energy-limited states: mechanisms that blunt the signaling of cell death VL - 211 SP - 1829 KW - apoptosis KW - mitochondria AU - Hand, Steven AU - Menze, Michael PY - 2008/06/15/ UR - http://dx.doi.org/10.1242/jeb.000299 ER -