Ethics in the design and conduct of clinical trials. Export

@article{citeulike:4365670, abstract = {In this article, I outline some of the important ethical issues in the design and conduct of clinical research. To set the appropriate context, I first sketch some of the most notorious examples of unethical research and explain how the ethics of research came to be recognized and articulated, especially in public declarations. Next I describe the basic ethical principles that can be of assistance in understanding the relevant ethical issues encountered in clinical research. I then outline the ethical implications associated with selected issues in research design: randomization, use of placebos, confidentiality, and selection of participants. Finally, I discuss some of the ethical considerations involved in the research process: obtaining valid informed consent, dealing with interim results, and the responsible conduct of research. Although the scope of this article does not permit a detailed analysis of any of these particular issues, I have attempted to provide a sense of the relevant concerns and to point the reader towards literature appropriate for further discussion of them.}, author = {Sugarman, J.}, citeulike-article-id = {4365670}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12119856}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12119856}, issn = {0193-936X}, journal = {Epidemiologic reviews}, keywords = {clinical-trials, ire, taskr}, number = {1}, pages = {54--58}, posted-at = {2009-04-19 22:12:58}, priority = {2}, title = {Ethics in the design and conduct of clinical trials.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12119856}, volume = {24}, year = {2002} }

TY - JOUR ID - citeulike:4365670 L3 - citeulike-article-id:4365670 N2 - In this article, I outline some of the important ethical issues in the design and conduct of clinical research. To set the appropriate context, I first sketch some of the most notorious examples of unethical research and explain how the ethics of research came to be recognized and articulated, especially in public declarations. Next I describe the basic ethical principles that can be of assistance in understanding the relevant ethical issues encountered in clinical research. I then outline the ethical implications associated with selected issues in research design: randomization, use of placebos, confidentiality, and selection of participants. Finally, I discuss some of the ethical considerations involved in the research process: obtaining valid informed consent, dealing with interim results, and the responsible conduct of research. Although the scope of this article does not permit a detailed analysis of any of these particular issues, I have attempted to provide a sense of the relevant concerns and to point the reader towards literature appropriate for further discussion of them. IS - 1 JF - Epidemiologic reviews SN - 0193-936X EP - 58 TI - Ethics in the design and conduct of clinical trials. VL - 24 SP - 54 KW - clinical-trials KW - ire KW - taskr AU - Sugarman, J PY - 2002/// UR - http://view.ncbi.nlm.nih.gov/pubmed/12119856 ER -