Seven vulnerabilities in the pediatric research subject. Export

@article{citeulike:4369038, abstract = {Most recent thinking about the vulnerability of research subjects uses a "subpopulation" focus. So conceived, the problem is to work out special standards for prisoners, pregnant women, the mentally ill, children, and similar groups. In contrast, an "analytical" approach would identify characteristics that are criteria for vulnerability. Using these criteria, one could support a judgment that certain individuals are vulnerable and identify needed accommodations if they are to serve as research subjects. Seven such characteristics can be evident in children: they commonly lack the capacity to make mature decisions; they are subject to the authority of others; they (and their parents) may be deferential in ways that can mask underlying dissent; their rights and interests may be socially undervalued; they may have acute medical conditions requiring immediate decisions not consistent with informed consent; they may have serious medical conditions that cannot be effectively treated; and they (and their parents) may lack important socially distributed goods. Each of these vulnerabilities can call for special care in the design and implementation of research protocols.}, author = {Kipnis, K.}, citeulike-article-id = {4369038}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12943266}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12943266}, issn = {1386-7415}, journal = {Theoretical medicine and bioethics}, keywords = {ire, pediatrics, taskr}, number = {2}, pages = {107--120}, posted-at = {2009-04-20 14:01:17}, priority = {2}, title = {Seven vulnerabilities in the pediatric research subject.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12943266}, volume = {24}, year = {2003} }

TY - JOUR ID - citeulike:4369038 L3 - citeulike-article-id:4369038 N2 - Most recent thinking about the vulnerability of research subjects uses a "subpopulation" focus. So conceived, the problem is to work out special standards for prisoners, pregnant women, the mentally ill, children, and similar groups. In contrast, an "analytical" approach would identify characteristics that are criteria for vulnerability. Using these criteria, one could support a judgment that certain individuals are vulnerable and identify needed accommodations if they are to serve as research subjects. Seven such characteristics can be evident in children: they commonly lack the capacity to make mature decisions; they are subject to the authority of others; they (and their parents) may be deferential in ways that can mask underlying dissent; their rights and interests may be socially undervalued; they may have acute medical conditions requiring immediate decisions not consistent with informed consent; they may have serious medical conditions that cannot be effectively treated; and they (and their parents) may lack important socially distributed goods. Each of these vulnerabilities can call for special care in the design and implementation of research protocols. IS - 2 JF - Theoretical medicine and bioethics SN - 1386-7415 EP - 120 TI - Seven vulnerabilities in the pediatric research subject. VL - 24 SP - 107 KW - ire KW - pediatrics KW - taskr AU - Kipnis, K PY - 2003/// UR - http://view.ncbi.nlm.nih.gov/pubmed/12943266 ER -