Transcript- and tissue-specific imprinting of a tumour suppressor gene. Export

@article{citeulike:3394019, abstract = {The Bladder Cancer-Associated Protein gene (BLCAP; previously BC10) is a tumour suppressor that limits cell proliferation and stimulates apoptosis. BLCAP protein or message are downregulated or absent in a variety of human cancers. In mouse and human, the first intron of Blcap/BLCAP contains the distinct Neuronatin (Nnat/NNAT) gene. Nnat is an imprinted gene that is exclusively expressed from the paternally inherited allele. Previous studies found no evidence for imprinting of Blcap in mouse or human. Here we show that Blcap is imprinted in mouse and human brain, but not in other mouse tissues. Moreover, Blcap produces multiple distinct transcripts that exhibit reciprocal allele-specific expression in both mouse and human. We propose that the tissue-specific imprinting of Blcap is due to the particularly high transcriptional activity of Nnat in brain, as has been suggested previously for the similarly organised and imprinted murine Commd1/U2af1-rs1 locus. For Commd1/U2af1-rs1 we show that it too produces distinct transcript variants with reciprocal allele-specific expression. The imprinted expression of BLCAP and its interplay with NNAT at the transcriptional level may be relevant to human carcinogenesis.}, author = {Schulz, Reiner and McCole, Ruth and Woodfine, Kathryn and Wood, Andrew J J. and Chahal, Mandeep and Monk, David and Moore, Gudrun E E. and Oakey, Rebecca J J.}, citeulike-article-id = {3394019}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18836209}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18836209}, day = {4}, issn = {1460-2083}, journal = {Human molecular genetics}, keywords = {brain, imprinting}, month = {October}, posted-at = {2009-01-17 13:26:58}, priority = {0}, title = {Transcript- and tissue-specific imprinting of a tumour suppressor gene.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18836209}, year = {2008} }

TY - JOUR ID - citeulike:3394019 L3 - citeulike-article-id:3394019 N2 - The Bladder Cancer-Associated Protein gene (BLCAP; previously BC10) is a tumour suppressor that limits cell proliferation and stimulates apoptosis. BLCAP protein or message are downregulated or absent in a variety of human cancers. In mouse and human, the first intron of Blcap/BLCAP contains the distinct Neuronatin (Nnat/NNAT) gene. Nnat is an imprinted gene that is exclusively expressed from the paternally inherited allele. Previous studies found no evidence for imprinting of Blcap in mouse or human. Here we show that Blcap is imprinted in mouse and human brain, but not in other mouse tissues. Moreover, Blcap produces multiple distinct transcripts that exhibit reciprocal allele-specific expression in both mouse and human. We propose that the tissue-specific imprinting of Blcap is due to the particularly high transcriptional activity of Nnat in brain, as has been suggested previously for the similarly organised and imprinted murine Commd1/U2af1-rs1 locus. For Commd1/U2af1-rs1 we show that it too produces distinct transcript variants with reciprocal allele-specific expression. The imprinted expression of BLCAP and its interplay with NNAT at the transcriptional level may be relevant to human carcinogenesis. JF - Human molecular genetics SN - 1460-2083 TI - Transcript- and tissue-specific imprinting of a tumour suppressor gene. KW - brain KW - imprinting AU - Schulz, Reiner AU - McCole, Ruth AU - Woodfine, Kathryn AU - Wood, Andrew J AU - Chahal, Mandeep AU - Monk, David AU - Moore, Gudrun E AU - Oakey, Rebecca J PY - 2008/10/04/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18836209 ER -