Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Export

@article{citeulike:4278092, abstract = {In response to DNA damage, eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin. Chromatin recruitment often entails ubiquitination of a damage-specific DNA repair protein, interaction with a ubiquitin binding factor, assembly of a multisubunit DNA repair complex, and eventually a deubiquitination event once the DNA repair reaction has been completed. This review focuses on the recent discoveries in the Fanconi Anemia (FA) and DNA double-strand break (DSB) repair pathways, which underscore the importance of regulated chromatin loading in the DNA damage response. Interestingly, these two pathways share several features, suggesting a more general mechanism for DNA-repair regulation.}, author = {Cohn, M. A. and D'Andrea, A. D.}, citeulike-article-id = {4278092}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.molcel.2008.10.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18995829}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18995829}, day = {7}, doi = {10.1016/j.molcel.2008.10.009}, issn = {1097-4164}, journal = {Molecular cell}, keywords = {eukaryote, repair}, month = {November}, number = {3}, pages = {306--312}, posted-at = {2009-04-06 11:33:57}, priority = {2}, title = {Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.}, url = {http://dx.doi.org/10.1016/j.molcel.2008.10.009}, volume = {32}, year = {2008} }

TY - JOUR ID - citeulike:4278092 L3 - citeulike-article-id:4278092 N2 - In response to DNA damage, eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin. Chromatin recruitment often entails ubiquitination of a damage-specific DNA repair protein, interaction with a ubiquitin binding factor, assembly of a multisubunit DNA repair complex, and eventually a deubiquitination event once the DNA repair reaction has been completed. This review focuses on the recent discoveries in the Fanconi Anemia (FA) and DNA double-strand break (DSB) repair pathways, which underscore the importance of regulated chromatin loading in the DNA damage response. Interestingly, these two pathways share several features, suggesting a more general mechanism for DNA-repair regulation. IS - 3 JF - Molecular cell SN - 1097-4164 EP - 312 TI - Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. VL - 32 SP - 306 KW - eukaryote KW - repair AU - Cohn, MA AU - D'Andrea, AD PY - 2008/11/07/ UR - http://dx.doi.org/10.1016/j.molcel.2008.10.009 ER -