Evidence for dynamically organized modularity in the yeast protein|[ndash]|protein interaction network Export

@article{jing2004, abstract = {In apparently scale-free protein–protein interaction networks, or 'interactome' networks1, 2, most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and non-biological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs1. A link between the potential scale-free topology of interactome networks and genetic robustness3, 4 seems to exist, because knockouts of yeast genes5, 6 encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs1. Here we investigate how hubs might contribute to robustness and other cellular properties for protein–protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processes—or modules7 —to each other, whereas party hubs function inside modules.}, author = {Han, Jing-Dong J. and Bertin, Nicolas and Hao, Tong and Goldberg, Debra S. and Berriz, Gabriel F. and Zhang, Lan V. and Dupuy, Denis and Walhout, Albertha J. M. and Cusick, Michael E. and Roth, Frederick P. and Vidal, Marc}, citeulike-article-id = {227174}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature02555}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature02555}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15190252}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15190252}, day = {09}, doi = {10.1038/nature02555}, issn = {0028-0836}, journal = {Nature}, keywords = {hubs, networks, ppi}, month = {July}, number = {6995}, pages = {88--93}, posted-at = {2009-10-27 14:53:00}, priority = {2}, publisher = {Nature Publishing Group}, title = {Evidence for dynamically organized modularity in the yeast protein|[ndash]|protein interaction network}, url = {http://dx.doi.org/10.1038/nature02555}, volume = {430}, year = {2004} }

TY - JOUR ID - jing2004 L3 - citeulike-article-id:227174 N2 - In apparently scale-free protein–protein interaction networks, or 'interactome' networks1, 2, most proteins interact with few partners, whereas a small but significant proportion of proteins, the 'hubs', interact with many partners. Both biological and non-biological scale-free networks are particularly resistant to random node removal but are extremely sensitive to the targeted removal of hubs1. A link between the potential scale-free topology of interactome networks and genetic robustness3, 4 seems to exist, because knockouts of yeast genes5, 6 encoding hubs are approximately threefold more likely to confer lethality than those of non-hubs1. Here we investigate how hubs might contribute to robustness and other cellular properties for protein–protein interactions dynamically regulated both in time and in space. We uncovered two types of hub: 'party' hubs, which interact with most of their partners simultaneously, and 'date' hubs, which bind their different partners at different times or locations. Both in silico studies of network connectivity and genetic interactions described in vivo support a model of organized modularity in which date hubs organize the proteome, connecting biological processes—or modules7 —to each other, whereas party hubs function inside modules. IS - 6995 JF - Nature SN - 0028-0836 EP - 93 TI - Evidence for dynamically organized modularity in the yeast protein|[ndash]|protein interaction network PB - Nature Publishing Group VL - 430 SP - 88 KW - hubs KW - networks KW - ppi AU - Han, Jing-Dong AU - Bertin, Nicolas AU - Hao, Tong AU - Goldberg, Debra AU - Berriz, Gabriel AU - Zhang, Lan AU - Dupuy, Denis AU - Walhout, Albertha AU - Cusick, Michael AU - Roth, Frederick AU - Vidal, Marc PY - 2004/07/09/ UR - http://dx.doi.org/10.1038/nature02555 ER -