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Nature Reviews Cancer, Vol. 10, No. 2. (01 February 2010), pp. 130-137, doi:10.1038/nrc2787 Key: citeulike:6582814
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Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies that are currently being used to identify new therapeutic combinations of kinase targets.
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