Molecular Pharmacology of Cancer Therapy in Human Colorectal Cancer by Gene Expression Profiling Export

@article{citeulike:1239834, abstract = {Global gene expression profiling has potential for elucidating the complex cellular effects and mechanisms of action of novel targeted anticancer agents or existing chemotherapeutics for which the precise molecular mechanism of action may be unclear. In this study, decreased expression of genes required for RNA and protein synthesis, and for metabolism were detected in rectal cancer biopsies taken from patients during a 5-fluorouracil infusion. Our observations demonstrate that this approach is feasible and can detect responses that may have otherwise been missed by conventional methods. The results suggested new mechanism-based combination treatments for colorectal cancer and demonstrated that expression profiling could provide valuable information on the molecular pharmacology of established and novel drugs.}, author = {Clarke, Paul A. and George, Mark L. and Easdale, Sandra and Cunningham, David and Swift, Ian R. and Hill, Mark E. and Tait, Diana M. and Workman, Paul}, citeulike-article-id = {1239834}, citeulike-linkout-0 = {http://cancerres.aacrjournals.org/cgi/content/abstract/63/20/6855}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14583483}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14583483}, day = {15}, journal = {Cancer Res}, keywords = {cancer, colon, drug, response}, month = {October}, number = {20}, pages = {6855--6863}, posted-at = {2007-04-20 15:40:35}, priority = {0}, title = {Molecular Pharmacology of Cancer Therapy in Human Colorectal Cancer by Gene Expression Profiling}, url = {http://cancerres.aacrjournals.org/cgi/content/abstract/63/20/6855}, volume = {63}, year = {2003} }

TY - JOUR ID - citeulike:1239834 L3 - citeulike-article-id:1239834 N2 - Global gene expression profiling has potential for elucidating the complex cellular effects and mechanisms of action of novel targeted anticancer agents or existing chemotherapeutics for which the precise molecular mechanism of action may be unclear. In this study, decreased expression of genes required for RNA and protein synthesis, and for metabolism were detected in rectal cancer biopsies taken from patients during a 5-fluorouracil infusion. Our observations demonstrate that this approach is feasible and can detect responses that may have otherwise been missed by conventional methods. The results suggested new mechanism-based combination treatments for colorectal cancer and demonstrated that expression profiling could provide valuable information on the molecular pharmacology of established and novel drugs. IS - 20 JF - Cancer Res EP - 6863 TI - Molecular Pharmacology of Cancer Therapy in Human Colorectal Cancer by Gene Expression Profiling VL - 63 SP - 6855 KW - cancer KW - colon KW - drug KW - response AU - Clarke, Paul AU - George, Mark AU - Easdale, Sandra AU - Cunningham, David AU - Swift, Ian AU - Hill, Mark AU - Tait, Diana AU - Workman, Paul PY - 2003/10/15/ UR - http://cancerres.aacrjournals.org/cgi/content/abstract/63/20/6855 ER -