Molecular interactions in the Vogelstein model of colorectal carcinoma Export

@article{citeulike:1272238, abstract = {In 1990, Fearon and Vogelstein proposed a model of successive genetic changes leading to colorectal cancer (CRC), in which a number of genes were involved, including APC (adenopolyposis coli), k-Ras, DCC, and p53 [1]. The original proposal stressed that mutations in these genes were essential for the development of CRC, rather than specifying the exact sequence of changes. Subsequent research over almost 10 years has revealed much information on the function of the key genes in the model, which will be reviewed first. The data which have been gathered about the interactions of their products will be examined next. Finally, the impact of these new data on the Vogelstein model will be discussed.}, author = {Arends, Jan W.}, citeulike-article-id = {1272238}, journal = {Journal of Pathology}, keywords = {vogelstein}, posted-at = {2007-05-02 16:13:40}, priority = {2}, title = {Molecular interactions in the Vogelstein model of colorectal carcinoma} }

TY - JOUR ID - citeulike:1272238 L3 - citeulike-article-id:1272238 N2 - In 1990, Fearon and Vogelstein proposed a model of successive genetic changes leading to colorectal cancer (CRC), in which a number of genes were involved, including APC (adenopolyposis coli), k-Ras, DCC, and p53 [1]. The original proposal stressed that mutations in these genes were essential for the development of CRC, rather than specifying the exact sequence of changes. Subsequent research over almost 10 years has revealed much information on the function of the key genes in the model, which will be reviewed first. The data which have been gathered about the interactions of their products will be examined next. Finally, the impact of these new data on the Vogelstein model will be discussed. JF - Journal of Pathology TI - Molecular interactions in the Vogelstein model of colorectal carcinoma KW - vogelstein AU - Arends, Jan ER -