The significance of unstable chromosomes in colorectal cancer Export

@article{citeulike:1272254, abstract = {A very large fraction of cancers have an abnormal genetic content, called aneuploidy, which is characterized by changes in chromosome structure and number. One explanation for this aneuploidy is chromosomal instability, in which cancer cells gain or lose whole chromosomes or large fractions of chromosomes at a greatly increased rate compared with normal cells. Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis.}, author = {Rajagopalan, Harith and Nowak, Martin A. and Vogelstein, Bert and Lengauer, Christoph}, citeulike-article-id = {1272254}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrc1165}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrc1165}, day = {01}, doi = {10.1038/nrc1165}, issn = {1474-175X}, journal = {Nature Reviews Cancer}, keywords = {vogelstein}, month = {September}, number = {9}, pages = {695--701}, posted-at = {2007-05-02 16:21:15}, priority = {2}, publisher = {Nature Publishing Group}, title = {The significance of unstable chromosomes in colorectal cancer}, url = {http://dx.doi.org/10.1038/nrc1165}, volume = {3}, year = {2003} }

TY - JOUR ID - citeulike:1272254 L3 - citeulike-article-id:1272254 N2 - A very large fraction of cancers have an abnormal genetic content, called aneuploidy, which is characterized by changes in chromosome structure and number. One explanation for this aneuploidy is chromosomal instability, in which cancer cells gain or lose whole chromosomes or large fractions of chromosomes at a greatly increased rate compared with normal cells. Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis. IS - 9 JF - Nature Reviews Cancer SN - 1474-175X EP - 701 TI - The significance of unstable chromosomes in colorectal cancer PB - Nature Publishing Group VL - 3 SP - 695 KW - vogelstein AU - Rajagopalan, Harith AU - Nowak, Martin AU - Vogelstein, Bert AU - Lengauer, Christoph PY - 2003/09/01/ UR - http://dx.doi.org/10.1038/nrc1165 ER -