Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers Export

@article{citeulike:1557177, abstract = {Protein tyrosine phosphorylation, mediated by the balanced action of tyrosine kinases and phosphatases, contributes to the regulation of the growth, migration, and invasion of normal and malignant cells. Among tyrosine phosphatases, low molecular weight protein tyrosine phosphatases (LMW-PTP) have been recognized as a possible "positive factor" in tumour onset and progression. The aim of this work was to assess whether LMW-PTP are differentially expressed in normal and malignant tissues. Using real-time PCR analysis we evaluated the expression levels of total LMW-PTP mRNA in surgical samples of breast, colon and lung cancers (63, 60, and 58, respectively), and in their paired adjacent not affected tissues. Moreover, the same analysis was carried out on a group of neuroblastomas (25 cases). Significant correlations between LMW-PTP overexpression and the most common clinical-pathological features of cancers exist. In colon cancer and neuroblastoma increased total LMW-PTP mRNA expression correlates with unfavourable outcome. While LMW-PTP mRNA expression increases in tumour samples, the relative contribution of the different isoforms does not change. Our findings indicate that LMW-PTP can be considered an oncogene as it is overexpressed in different tumour types and suggests that LMW-PTP enhanced expression is generally prognostic for a more aggressive cancer.}, author = {Malentacchi, Francesca and Marzocchini, Riccardo and Gelmini, Stefania and Orlando, Claudio and Serio, Mario and Ramponi, Giampietro and Raugei, Giovanni}, citeulike-article-id = {1557177}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbrc.2005.06.176}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WBK-4GM44M7-1/2/5bee78a20ab12b23adf335b722ca86a9}, day = {2}, doi = {10.1016/j.bbrc.2005.06.176}, journal = {Biochemical and Biophysical Research Communications}, keywords = {cancer, colon, genes}, month = {September}, number = {3}, pages = {875--883}, posted-at = {2007-08-13 09:36:56}, priority = {2}, title = {Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers}, url = {http://dx.doi.org/10.1016/j.bbrc.2005.06.176}, volume = {334}, year = {2005} }

TY - JOUR ID - citeulike:1557177 L3 - citeulike-article-id:1557177 N2 - Protein tyrosine phosphorylation, mediated by the balanced action of tyrosine kinases and phosphatases, contributes to the regulation of the growth, migration, and invasion of normal and malignant cells. Among tyrosine phosphatases, low molecular weight protein tyrosine phosphatases (LMW-PTP) have been recognized as a possible "positive factor" in tumour onset and progression. The aim of this work was to assess whether LMW-PTP are differentially expressed in normal and malignant tissues. Using real-time PCR analysis we evaluated the expression levels of total LMW-PTP mRNA in surgical samples of breast, colon and lung cancers (63, 60, and 58, respectively), and in their paired adjacent not affected tissues. Moreover, the same analysis was carried out on a group of neuroblastomas (25 cases). Significant correlations between LMW-PTP overexpression and the most common clinical-pathological features of cancers exist. In colon cancer and neuroblastoma increased total LMW-PTP mRNA expression correlates with unfavourable outcome. While LMW-PTP mRNA expression increases in tumour samples, the relative contribution of the different isoforms does not change. Our findings indicate that LMW-PTP can be considered an oncogene as it is overexpressed in different tumour types and suggests that LMW-PTP enhanced expression is generally prognostic for a more aggressive cancer. IS - 3 JF - Biochemical and Biophysical Research Communications EP - 883 TI - Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers VL - 334 SP - 875 KW - cancer KW - colon KW - genes AU - Malentacchi, Francesca AU - Marzocchini, Riccardo AU - Gelmini, Stefania AU - Orlando, Claudio AU - Serio, Mario AU - Ramponi, Giampietro AU - Raugei, Giovanni PY - 2005/09/02/ UR - http://dx.doi.org/10.1016/j.bbrc.2005.06.176 ER -