The role of insulin and the adipocytokines in regulation of vascular endothelial function. Export

@article{citeulike:256066, abstract = {Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability, is associated with obesity, insulin resistance and Type II diabetes. Insulin has been demonstrated to have direct effects on the endothelium to increase NO bioavailability. Therefore altered insulin signalling in the endothelium represents a candidate mechanism underlying the association between insulin resistance and endothelial dysfunction. In recent years, it has become apparent that insulin sensitivity is regulated by the adipocytokines, a group of bioactive proteins secreted by adipose tissue. Secretion of adipocytokines is altered in obese individuals and there is increasing evidence that the adipocytokines have direct effects on the vascular endothelium. A number of current antidiabetic strategies have been demonstrated to have beneficial effects on endothelial function and to alter adipocytokine concentrations in addition to their effects on glucose homoeostasis. In this review we will explore the notion that the association between insulin resistance and endothelial dysfunction is accounted for by adipocytokine action on the endothelium. In addition, we examine the effects of weight loss, exercise and antidiabetic drugs on adipocytokine availability and endothelial function.}, address = {Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.}, author = {Ritchie, S. A. and Ewart, M. A. and Perry, C. G. and Connell, J. M. and Salt, I. P.}, citeulike-article-id = {256066}, citeulike-linkout-0 = {http://dx.doi.org/10.1042/CS20040190}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15324298}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15324298}, doi = {10.1042/CS20040190}, issn = {0143-5221}, journal = {Clin Sci (Lond)}, keywords = {adipocytokines, endothelialfunction, endothelium, insulin, insulinresistance, insulinsignalling}, month = {December}, number = {6}, pages = {519--532}, posted-at = {2005-07-14 14:16:41}, priority = {2}, title = {The role of insulin and the adipocytokines in regulation of vascular endothelial function.}, url = {http://dx.doi.org/10.1042/CS20040190}, volume = {107}, year = {2004} }

TY - JOUR ID - citeulike:256066 L3 - citeulike-article-id:256066 N2 - Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability, is associated with obesity, insulin resistance and Type II diabetes. Insulin has been demonstrated to have direct effects on the endothelium to increase NO bioavailability. Therefore altered insulin signalling in the endothelium represents a candidate mechanism underlying the association between insulin resistance and endothelial dysfunction. In recent years, it has become apparent that insulin sensitivity is regulated by the adipocytokines, a group of bioactive proteins secreted by adipose tissue. Secretion of adipocytokines is altered in obese individuals and there is increasing evidence that the adipocytokines have direct effects on the vascular endothelium. A number of current antidiabetic strategies have been demonstrated to have beneficial effects on endothelial function and to alter adipocytokine concentrations in addition to their effects on glucose homoeostasis. In this review we will explore the notion that the association between insulin resistance and endothelial dysfunction is accounted for by adipocytokine action on the endothelium. In addition, we examine the effects of weight loss, exercise and antidiabetic drugs on adipocytokine availability and endothelial function. IS - 6 JF - Clin Sci (Lond) SN - 0143-5221 AD - Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. EP - 532 TI - The role of insulin and the adipocytokines in regulation of vascular endothelial function. VL - 107 SP - 519 KW - adipocytokines KW - endothelialfunction KW - endothelium KW - insulin KW - insulinresistance KW - insulinsignalling AU - Ritchie, SA AU - Ewart, MA AU - Perry, CG AU - Connell, JM AU - Salt, IP PY - 2004/12// UR - http://dx.doi.org/10.1042/CS20040190 ER -