Perspectives on PKCtheta in T cell activation. Export

@article{citeulike:282273, abstract = {Upon stimulation by environmental signals, T lymphocytes develop an intricate set of signal-dependent responses including remodeling of the actin cytoskeleton, the development of cellular polarity, the initiation of second-messenger cascades, entry into cell cycle, differentiation and effector function. The integration of TCR and costimulatory signaling is critical to the successful initiation of the T cell activation program, and the serine/threonine kinase PKCtheta is an important site of signal integration in the process of T cell activation. We provide an overview of T cell signaling, and then go on to assess our understanding of the regulation of PKCtheta activity, its target proteins and its role in T cell activation and the production of T cell survival factors such as IL-2.}, address = {Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. csedwick@liai.org}, author = {Sedwick, C. E. and Altman, A.}, citeulike-article-id = {282273}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.molimm.2004.01.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15220003}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15220003}, doi = {10.1016/j.molimm.2004.01.007}, issn = {0161-5890}, journal = {Mol Immunol}, keywords = {inflammation, insulinresistance, nfkb, pkc}, month = {July}, number = {6-7}, pages = {675--686}, posted-at = {2005-08-15 13:32:57}, priority = {2}, title = {Perspectives on PKCtheta in T cell activation.}, url = {http://dx.doi.org/10.1016/j.molimm.2004.01.007}, volume = {41}, year = {2004} }

TY - JOUR ID - citeulike:282273 L3 - citeulike-article-id:282273 N2 - Upon stimulation by environmental signals, T lymphocytes develop an intricate set of signal-dependent responses including remodeling of the actin cytoskeleton, the development of cellular polarity, the initiation of second-messenger cascades, entry into cell cycle, differentiation and effector function. The integration of TCR and costimulatory signaling is critical to the successful initiation of the T cell activation program, and the serine/threonine kinase PKCtheta is an important site of signal integration in the process of T cell activation. We provide an overview of T cell signaling, and then go on to assess our understanding of the regulation of PKCtheta activity, its target proteins and its role in T cell activation and the production of T cell survival factors such as IL-2. IS - 6-7 JF - Mol Immunol SN - 0161-5890 AD - Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA. csedwick@liai.org EP - 686 TI - Perspectives on PKCtheta in T cell activation. VL - 41 SP - 675 KW - inflammation KW - insulinresistance KW - nfkb KW - pkc AU - Sedwick, CE AU - Altman, A PY - 2004/07// UR - http://dx.doi.org/10.1016/j.molimm.2004.01.007 ER -