csainsbury's Aljada:A [3 articles]

Abstract

Objective: Elevation of free fatty acids (FFA) by the infusion of triglyceride-heparin emulsion infusion(TG-Hep) causes insulin resistance(IR). We examined the effect of insulin sensitizer(rosiglitazone) on FFA induced IR. Design: 9 obese subjects underwent a 6-hour infusion of TG-Hep before and after 6 weeks of rosiglitazone(8 mg/day) treatment. Hyperinsulinemic euglycemic clamps were performed during 0-2 h and 4-6 h of TG-Hep. Results: Following rosiglitazone for 6 weeks, fasting FFA concentration fell, but not significantly (489 +/- 63 at 0w; 397 +/- 58 ...

Abstract

In view of the fact that insulin resistance is associated with atherogenesis and that troglitazone, an insulin sensitizer, has anti-inflammatory effects, which may be potentially antiatherogenic in the long term, we have now investigated whether insulin has potential anti-inflammatory effects. We infused 2.0 to 2.5 IU/h in 5% dextrose (100 mL/h) iv into 10 obese subjects for 4 h followed by 5% dextrose alone for 2 h. The rate of insulin infusion was varied to maintain glucose concentrations as close to ...

Abstract

To test the possible acute proinflammatory effects of fatty acids, we induced an increase in plasma free fatty acid (FFA) concentrations after a lipid and heparin infusion for 4 h in 10 healthy subjects. We determined the nuclear factor-kappaB (NF-kappaB) binding activity in mononuclear cells (MNCs), the p65 subunit of NF-kappaB, reactive oxygen species (ROS) generation by MNC, and polymorphonuclear leukocytes (PMN). Brachial artery reactivity, using postischemic flow-mediated dilation, was also measured. NF-kappaB binding activity in the MNC nuclear extracts increased ...