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Context is everything: activators can also repress.

by: Richard Festenstein, Jackson P. Chan
Nature structural & molecular biology, Vol. 19, No. 10. (4 October 2012), pp. 973-975, doi:10.1038/nsmb.2401  Key: citeulike:11406587

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Abstract

Maintenance of genome integrity, cell division and gene expression have all been shown to be regulated by the condensation of DNA into heterochromatin. In a study published in this issue, Bulut-Karslioglu et al. reveal a new heterochromatin function for transcription factors in a mammalian system. They show that instead of activating gene expression, in the context of heterochromatic repeats, specific transcription factors are necessary for the maintenance of transcriptional repression and heterochromatin.


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