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Integrative genomics in cardiovascular medicine.

by: James S. Ware, Enrico Petretto, Stuart A. Cook
Cardiovascular research (27 September 2012), doi:10.1093/cvr/cvs303  Key: citeulike:11422074

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Abstract

Integrative Genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next generation sequencing datasets with quantitative phenotypes at the molecular, cellular and whole heart level using advanced modelling approaches provides an unprecedented opportunity for cardiovascular science.


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