Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction. Export

@article{citeulike:6098517, abstract = {The ventral tegmental area (VTA) is a brain region centrally involved in the development and expression of a variety of behaviors associated with drug use. Orexin/hypocretin (ox/hcrt) and corticotropin releasing factor (CRF) are both peptides released into the VTA, and an increasing number of studies show that both ox/hcrt and CRF in the VTA exert powerful modulatory effects on a variety of behaviors produced by drugs of abuse. Importantly, at a cellular and synaptic level, there is strong evidence supporting the hypothesis that these neuropeptides exert similar effects onto N-methyl-d-aspartate receptors (NMDARs) expressed in VTA neurons, suggesting a common molecular target in the actions of these peptides on this circuitry and ultimately on behaviors associated with drug use. In this review, we discuss emerging evidence that ox/hcrt and CRF directly target dopamine neurons by modulating excitatory synaptic activity, and that interaction of ox/hcrt and CRF may play a central role in addictive behaviors. Understanding these interactions in more detail may suggest new therapeutic targets in the treatment of relapse to substance abuse.}, author = {Borgland, Stephanie L. and Ungless, Mark A. and Bonci, Antonello}, citeulike-article-id = {6098517}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.brainres.2009.10.068}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19891960}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19891960}, day = {3}, doi = {10.1016/j.brainres.2009.10.068}, issn = {1872-6240}, journal = {Brain research}, keywords = {neurophysiology}, month = {November}, posted-at = {2009-11-11 17:26:17}, priority = {2}, title = {Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction.}, url = {http://dx.doi.org/10.1016/j.brainres.2009.10.068}, year = {2009} }

TY - JOUR ID - citeulike:6098517 L3 - citeulike-article-id:6098517 N2 - The ventral tegmental area (VTA) is a brain region centrally involved in the development and expression of a variety of behaviors associated with drug use. Orexin/hypocretin (ox/hcrt) and corticotropin releasing factor (CRF) are both peptides released into the VTA, and an increasing number of studies show that both ox/hcrt and CRF in the VTA exert powerful modulatory effects on a variety of behaviors produced by drugs of abuse. Importantly, at a cellular and synaptic level, there is strong evidence supporting the hypothesis that these neuropeptides exert similar effects onto N-methyl-d-aspartate receptors (NMDARs) expressed in VTA neurons, suggesting a common molecular target in the actions of these peptides on this circuitry and ultimately on behaviors associated with drug use. In this review, we discuss emerging evidence that ox/hcrt and CRF directly target dopamine neurons by modulating excitatory synaptic activity, and that interaction of ox/hcrt and CRF may play a central role in addictive behaviors. Understanding these interactions in more detail may suggest new therapeutic targets in the treatment of relapse to substance abuse. JF - Brain research SN - 1872-6240 TI - Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction. KW - neurophysiology AU - Borgland, Stephanie AU - Ungless, Mark AU - Bonci, Antonello PY - 2009/11/03/ UR - http://dx.doi.org/10.1016/j.brainres.2009.10.068 ER -