Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Export

@article{Kho04, abstract = {Identification of common mechanisms underlying organ development and primary tumor formation should yield new insights into tumor biology and facilitate the generation of relevant cancer models. We have developed a novel method to project the gene expression profiles of medulloblastomas (MBs)--human cerebellar tumors--onto a mouse cerebellar development sequence: postnatal days 1-60 (P1-P60). Genomically, human medulloblastomas were closest to mouse P1-P10 cerebella, and normal human cerebella were closest to mouse P30-P60 cerebella. Furthermore, metastatic MBs were highly associated with mouse P5 cerebella, suggesting that a clinically distinct subset of tumors is identifiable by molecular similarity to a precise developmental stage. Genewise, down- and up-regulated MB genes segregate to late and early stages of development, respectively. Comparable results for human lung cancer vis-a-vis the developing mouse lung suggest the generalizability of this multiscalar developmental perspective on tumor biology. Our findings indicate both a recapitulation of tissue-specific developmental programs in diverse solid tumors and the utility of tumor characterization on the developmental time axis for identifying novel aspects of clinical and biological behavior.}, author = {Kho, A. T. and Zhao, Q. and Cai, Z. and Butte, A. J. and Kim, J. Y. and Pomeroy, S. L. and Rowitch, D. H. and Kohane, I. S.}, citeulike-article-id = {3908875}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gad.1182504}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15075291}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15075291}, day = {15}, doi = {10.1101/gad.1182504}, issn = {0890-9369}, journal = {Genes \& development}, keywords = {cancer, motifs, mouse, senior-project}, month = {March}, number = {6}, pages = {629--640}, posted-at = {2009-01-19 16:45:48}, priority = {2}, title = {Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers.}, url = {http://dx.doi.org/10.1101/gad.1182504}, volume = {18}, year = {2004} }

TY - JOUR ID - Kho04 L3 - citeulike-article-id:3908875 N2 - Identification of common mechanisms underlying organ development and primary tumor formation should yield new insights into tumor biology and facilitate the generation of relevant cancer models. We have developed a novel method to project the gene expression profiles of medulloblastomas (MBs)--human cerebellar tumors--onto a mouse cerebellar development sequence: postnatal days 1-60 (P1-P60). Genomically, human medulloblastomas were closest to mouse P1-P10 cerebella, and normal human cerebella were closest to mouse P30-P60 cerebella. Furthermore, metastatic MBs were highly associated with mouse P5 cerebella, suggesting that a clinically distinct subset of tumors is identifiable by molecular similarity to a precise developmental stage. Genewise, down- and up-regulated MB genes segregate to late and early stages of development, respectively. Comparable results for human lung cancer vis-a-vis the developing mouse lung suggest the generalizability of this multiscalar developmental perspective on tumor biology. Our findings indicate both a recapitulation of tissue-specific developmental programs in diverse solid tumors and the utility of tumor characterization on the developmental time axis for identifying novel aspects of clinical and biological behavior. IS - 6 JF - Genes & development SN - 0890-9369 EP - 640 TI - Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. VL - 18 SP - 629 KW - cancer KW - motifs KW - mouse KW - senior-project AU - Kho, AT AU - Zhao, Q AU - Cai, Z AU - Butte, AJ AU - Kim, JY AU - Pomeroy, SL AU - Rowitch, DH AU - Kohane, IS PY - 2004/03/15/ UR - http://dx.doi.org/10.1101/gad.1182504 ER -