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A novel and convenient transformation of nitriles to aldehydes

by: Fred Xi, Fred Kamal, Mark A. Schenerman
Tetrahedron Letters, Vol. 43, No. 8. (February 2002), pp. 1395-1396, doi:10.1016/s0040-4039(02)00027-8  Key: citeulike:11474695

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Abstract

Various aromatic nitriles are reduced to the corresponding aldehydes by platinum(IV) oxide in aqueous formic acid with yields ranging from 76 to 94%. This mild method may be generally applied to multi-step organic synthesis. Various aromatic nitriles are reduced to the corresponding aldehydes by platinum(IV) oxide in aqueous formic acid with yields ranging from 76 to 94%. This mild method may be generally applied to multi-step organic synthesis.


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