Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene. Export

@article{citeulike:1882065, abstract = {The genomic regulatory network that controls gene expression ultimately determines form and function in each species. The operational nature of the regulatory programming specified in cis-regulatory DNA sequence was determined from a detailed functional analysis of a sea urchin control element that directs the expression of a gene in the endoderm during development. Spatial expression and repression, and the changing rate of transcription of this gene, are mediated by a complex and extended cis-regulatory system. The system may be typical of developmental cis-regulatory apparatus. All of its activities are integrated in the proximal element, which contains seven target sites for DNA binding proteins. A quantitative computational model of this regulatory element was constructed that explicitly reveals the logical interrelations hard-wired into the DNA.}, address = {Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.}, author = {Yuh, C. H. and Bolouri, H. and Davidson, E. H.}, citeulike-article-id = {1882065}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9506933}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9506933}, day = {20}, issn = {0036-8075}, journal = {Science}, keywords = {enhancer\_function, sea\_urchin}, month = {March}, number = {5358}, pages = {1896--1902}, posted-at = {2007-11-08 00:41:35}, priority = {2}, title = {Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9506933}, volume = {279}, year = {1998} }

TY - JOUR ID - citeulike:1882065 L3 - citeulike-article-id:1882065 N2 - The genomic regulatory network that controls gene expression ultimately determines form and function in each species. The operational nature of the regulatory programming specified in cis-regulatory DNA sequence was determined from a detailed functional analysis of a sea urchin control element that directs the expression of a gene in the endoderm during development. Spatial expression and repression, and the changing rate of transcription of this gene, are mediated by a complex and extended cis-regulatory system. The system may be typical of developmental cis-regulatory apparatus. All of its activities are integrated in the proximal element, which contains seven target sites for DNA binding proteins. A quantitative computational model of this regulatory element was constructed that explicitly reveals the logical interrelations hard-wired into the DNA. IS - 5358 JF - Science SN - 0036-8075 AD - Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. EP - 1902 TI - Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene. VL - 279 SP - 1896 KW - enhancer_function KW - sea_urchin AU - Yuh, CH AU - Bolouri, H AU - Davidson, EH PY - 1998/03/20/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9506933 ER -