| |
posted to no-tag
by cyberwulf
on 2012-02-24 00:03:15
Abstract
OBJECTIVE: The purpose of the present study was to measure the availability of energy-dense foods and sugar-sweetened beverages in pharmacies and to examine differences by pharmacy type and presence of a food policy. DESIGN: Trained research staff visited pharmacies (n 37) to measure shelf space and variety of snacks, candy and sugar-sweetened beverages available within 10 ft (3·05 m) of the pharmacy register. SETTING: Community ...
|
| |
Econometrica, Vol. 74, No. 1. (2006), pp. 235-267
posted to no-tag
by cyberwulf
on 2012-02-05 22:16:45
Abstract
Matching estimators for average treatment effects are widely used in evaluation research despite the fact that their large sample properties have not been established in many cases. The absence of formal results in this area may be partly due to the fact that standard asymptotic expansions do not apply to matching estimators with a fixed number of matches because such estimators are highly nonsmooth functionals of the data. In this article we develop new methods for analyzing the large sample properties ...
|
| |
Magnetic resonance imaging, Vol. 17, No. 10. (December 1999), pp. 1457-1468
posted to no-tag
by cyberwulf
on 2012-01-17 21:07:01
Abstract
High-resolution imaging techniques using noninvasive modalities such as magnetic resonance (MR) imaging are being pursued as in vivo cancer screening techniques in an attempt to eliminate the invasive nature of surgical biopsy. When acquiring high-resolution MR images for tissue screening, image fields of view have in the past been limited by the matrix sizes available in conventional MR scanners. We present here a technique that ...
|
| |
posted to no-tag
by cyberwulf
on 2012-01-10 17:02:00
|
| |
posted to no-tag
by cyberwulf ✚
on 2012-01-06 16:53:43
along with 1 person
guhjy
Abstract
Transforming growth factor beta (TGF-beta) is a pleiotropic cytokine with vital homeostatic functions. Aberrant TGF-beta expression is implicated in the pathogenesis of fibrosis in systemic sclerosis (SSc); thus, TGF-beta represents a molecular therapeutic target in this disease. Anti-TGF-beta monoclonal antibody has been evaluated in a small trial of early SSc, with disappointing results. Antibodies against the alphavbeta6 integrin that prevent latent TGF-beta activation, however, have ...
|
| |
posted to no-tag
by cyberwulf
on 2012-01-05 21:49:04
along with 1 person
guhjy
|
| |
Abstract
The performance of prediction models can be assessed using a variety of methods and metrics. Traditional measures for binary and survival outcomes include the Brier score to indicate overall model performance, the concordance (or c) statistic for discriminative ability (or area under the receiver operating characteristic [ROC] curve), and goodness-of-fit statistics for calibration.Several new measures have recently been proposed that can be seen as refinements ...
|
| |
by Emerging Risk Factors Collaboration, J. Danesh, S. Erqou, et al.M. Walker, S. G. Thompson, R. Tipping, C. Ford, S. Pressel, G. Walldius, I. Jungner, A. R. Folsom, L. E. Chambless, M. Knuiman, P. H. Whincup, S. G. Wannamethee, R. W. Morris, J. Willeit, S. Kiechl, P. Santer, A. Mayr, N. Wald, S. Ebrahim, D. A. Lawlor, J. W. Yarnell, J. Gallacher, E. Casiglia, V. Tikhonoff, P. J. Nietert, S. E. Sutherland, D. L. Bachman, J. E. Keil, M. Cushman, B. M. Psaty, R. P. Tracy, A. Tybjaerg-Hansen, B. G. Nordestgaard, R. Frikke-Schmidt, S. Giampaoli, L. Palmieri, S. Panico, D. Vanuzzo, L. Pilotto, L. Simons, J. McCallum, Y. Friedlander, F. G. Fowkes, A. J. Lee, F. B. Smith, J. Taylor, J. Guralnik, C. Phillips, R. Wallace, D. Blazer, K. T. Khaw, J. H. Jansson, C. Donfrancesco, V. Salomaa, K. Harald, P. Jousilahti, E. Vartiainen, M. Woodward, R. B. D'Agostino, P. A. Wolf, R. S. Vasan, M. J. Pencina, E. M. Bladbjerg, T. Jorgensen, L. Moller, J. Jespersen, R. Dankner, A. Chetrit, F. Lubin, A. Rosengren, L. Wilhelmsen, G. Lappas, H. Eriksson, C. Bjorkelund, P. Cremer, D. Nagel, R. Tilvis, T. Strandberg, B. Rodriguez, L. M. Bouter, R. J. Heine, J. M. Dekker, G. Nijpels, C. D. Stehouwer, E. Rimm, J. Pai, S. Sato, H. Iso, A. Kitamura, H. Noda, U. Goldbourt, V. Salomaa, J. T. Salonen, K. Nyyssönen, T-P P. Tuomainen, D. Deeg, J. L. Poppelaars, T. Meade, J. Cooper, B. Hedblad, G. Berglund, G. Engstrom, A. Döring, W. Koenig, C. Meisinger, W. Mraz, L. Kuller, R. Selmer, A. Tverdal, W. Nystad, R. Gillum, M. Mussolino, S. Hankinson, J. Manson, B. De Stavola, C. Knottenbelt, J. A. Cooper, K. A. Bauer, R. D. Rosenberg, S. Sato, Y. Naito, I. Holme, H. Nakagawa, H. Miura, P. Ducimetiere, X. Jouven, C. Crespo, M. Garcia-Palmieri, P. Amouyel, D. Arveiler, A. Evans, J. Ferrieres, H. Schulte, G. Assmann, J. Shepherd, C. Packard, N. Sattar, B. Cantin, B. Lamarche, J-P P. Després, G. R. Dagenais, E. Barrett-Connor, D. Wingard, R. Bettencourt, V. Gudnason, T. Aspelund, G. Sigurdsson, B. Thorsson, M. Trevisan, J. Witteman, I. Kardys, M. Breteler, A. Hofman, H. Tunstall-Pedoe, R. Tavendale, G. D. Lowe, Y. Ben-Shlomo, B. V. Howard, Y. Zhang, L. Best, J. Umans, A. Onat, T. W. Meade, I. Njolstad, E. Mathiesen, M. L. Lochen, T. Wilsgaard, J. M. Gaziano, M. Stampfer, P. Ridker, H. Ulmer, G. Diem, H. Concin, F. Rodeghiero, A. Tosetto, E. Brunner, M. Shipley, J. Buring, S. M. Cobbe, I. Ford, M. Robertson, Y. He, A. M. Ibanez, E. J. Feskens, D. Kromhout, R. Collins, E. Di Angelantonio, S. Kaptoge, S. Lewington, L. Orfei, L. Pennells, P. Perry, K. Ray, N. Sarwar, M. Scherman, A. Thompson, S. Watson, F. Wensley, I. R. White, A. M. Wood
posted to no-tag
by cyberwulf ✚
on 2012-01-05 21:39:27
along with 1 person
Terkko
Abstract
Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has established a central database on over 1.1 million participants from 104 prospective population-based studies, in which subsets have information on lipid ...
|
| |
by Peter Duewell, Hajime Kono, Katey J. Rayner, et al.Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, Eicke Latz
posted to no-tag
by cyberwulf
on 2012-01-05 19:59:00
Abstract
The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible to atherosclerosis, suggesting that endogenous substances initiate the inflammation. Mature atherosclerotic lesions contain macroscopic deposits of cholesterol crystals in the necrotic core, but their appearance late in atherogenesis had been thought to disqualify them as primary inflammatory stimuli. However, using ...
|
| |
Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome associated with abnormal inflammatory immune responses of the lung to noxious particles and gases. Cigarette smoke activates innate immune cells such as epithelial cells and macrophages by triggering pattern recognition receptors, either directly or indirectly via the release of damage-associated molecular patterns from stressed or dying cells. Activated dendritic cells induce adaptive immune responses encompassing T ...
|
| |
posted to no-tag
by cyberwulf
on 2011-11-14 18:21:42
Abstract
The large number of negative phase III trials in oncology over the last several years has renewed interest in refining phase II oncology clinical trials to maximize the chances of success in phase III testing. More efficient phase II study designs will improve our ability to identify promising agents for testing while accurately identifying nonefficacious agents. Recognizing that new paradigms of phase II trial designs need to be developed, the Clinical Trial Design Task Force of the National Cancer Institute (NCI) ...
|
| |
posted to no-tag
by cyberwulf ✚
on 2011-11-14 18:21:34
along with 1 person
guhjy
Abstract
The incorporation of biomarkers into the drug development process will improve understanding of how new therapeutics work and allow for more accurate identification of patients who will benefit from those therapies. Strategically planned biomarker evaluations in phase II studies may allow for the design of more efficient phase III trials and better screening of therapeutics for entry into phase III development, hopefully leading to increased chances of positive phase III trial results. Some examples of roles that a biomarker can play ...
|
| |
by Josep M. Llovet, Adrian M. Di Bisceglie, Jordi Bruix, et al.Barnett S. Kramer, Riccardo Lencioni, Andrew X. Zhu, Morris Sherman, Myron Schwartz, Michael Lotze, Jayant Talwalkar, Gregory J. Gores, for the Panel of Experts in HCC-Design Clinical Trials
Abstract
The design of clinical trials in hepatocellular carcinoma (HCC) is complex because many patients have concurrent liver disease, which can confound the assessment of clinical benefit. There is an urgent need for high-quality trials in this disease. An expert panel was convened by the American Association for the Study of Liver Diseases to develop guidelines that provide a common framework for designing trials to facilitate comparability of results. According to these guidelines, randomized phase 2 trials with a time-to-event primary endpoint, ...
|
| |
by Axel Hoos, Giorgio Parmiani, Kristen Hege, et al.Mario Sznol, Hans Loibner, Alexander Eggermont, Walter Urba, Brent Blumenstein, Natalie Sacks, Ulrich Keilholz, Geoffrey Nichol
posted to no-tag
by cyberwulf ✚
on 2011-11-14 18:17:07
|
| |
posted to no-tag
by cyberwulf ✚
on 2011-11-14 17:48:03
Abstract
The objectives of this paper are to (1) examine methods of using longitudinal data in designing comparative trials and calculating sample sizes or power and (2) show the effect of autocorrelation of repeated measures on the assessment of sample sizes. A statistical model with a simple regression structure for the mean trajectory of the longitudinal data and a two-parameter model for the correlations of within-individual observations given by corr(yt,yt+s) = γsθ is used. The methods are illustrated by considering a two-group ...
|
| |
Abstract
Future progress in improving cancer therapy can be expedited by better prioritization of new treatments for phase III evaluation. Historically, phase II trials have been key components in the prioritization process. There has been a long-standing interest in using phase II trials with randomization against a standard-treatment control arm or an additional experimental arm to provide greater assurance than afforded by comparison to historic controls that the new agent or regimen is promising and warrants further evaluation. Relevant trial designs that ...
|
| |
Journal of the National Cancer Institute, Vol. 100, No. 17. (3 September 2008), pp. 1204-1214, doi:10.1093/jnci/djn267
by Mahesh K. Parmar, Friederike M-S M. Barthel, Matthew Sydes, et al.Ruth Langley, Rick Kaplan, Elizabeth Eisenhauer, Mark Brady, Nicholas James, Michael A. Bookman, Ann-Marie M. Swart, Wendi Qian, Patrick Royston
posted to no-tag
by cyberwulf ✚
on 2011-11-14 03:02:59
Abstract
Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By ...
|
| |
Abstract
Clinical biomarker tests that aid in making treatment decisions will play an important role in achieving personalized medicine for cancer patients. Definitive evaluation of the clinical utility of these biomarkers requires conducting large randomized clinical trials (RCTs). Efficient RCT design is therefore crucial for timely introduction of these medical advances into clinical practice, and a variety of designs have been proposed for this purpose. To guide design and interpretation of RCTs evaluating biomarkers, we present an in-depth comparison of advantages and ...
|
| |
Abstract
This article reviews phase 2–3 clinical trial designs, including their genesis and the potential role of such designs in treatment evaluation. The paper begins with a discussion of the many scientific flaws in the conventional phase 2 → phase 3 treatment evaluation process that motivate phase 2–3 designs. This is followed by descriptions of some particular phase 2–3 designs that have been proposed, including two-stage designs to evaluate one experimental treatment, a design that accommodates both frontline and salvage therapy in ...
|
| |
posted to no-tag
by cyberwulf ✚
on 2011-11-14 02:56:44
|
| |
Abstract
Principal stratification has recently become a popular tool to address certain causal inference questions, particularly in dealing with post-randomization factors in randomized trials. Here, we analyze the conceptual basis for this framework and invite response to clarify the value of principal stratification in estimating causal effects of interest. ...
|
| |
Journal of Statistical Software, Vol. 42, No. 7. (June 2007), pp. 1-52
posted to no-tag
by cyberwulf
on 2011-08-11 20:56:03
|
| |
Abstract
Miettinen has derived the asymptotic power for testing for a difference between cases and controls with dichotomous response and one-to-one or one-to-R matching. In this paper the accuracy of Miettinen's estimates is assessed by comparison with results obtained by simulation for large samples and by exact computation of power for small samples. The relation between exact and asymptotic power is discussed. It is concluded that the asymptotic power function will suffice except in the rare case where small sample sizes can ...
|
| |
(01 December 2002)
posted to no-tag
by cyberwulf
on 2011-04-12 22:48:37
|
| |
posted to no-tag
by cyberwulf
on 2011-02-04 00:43:48
Abstract
Background Recently, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial published 7-year complete prostate cancer mortality results, which showed no benefit of screening with prostate specific antigen (PSA) and digital rectal examination (DRE). An issue of concern was the substantial level of ‘contamination’, or use of PSA and DRE in control arm men.Purpose To provide a detailed description of contamination in PLCO.Methods Surveys inquiring about the most recent PSA and DRE use were given to a sample of control ...
|
| |
by Fritz H. Schröder, Jonas Hugosson, Monique J. Roobol, et al.Teuvo L. Tammela, Stefano Ciatto, Vera Nelen, Maciej Kwiatkowski, Marcos Lujan, Hans Lilja, Marco Zappa, Louis J. Denis, Franz Recker, Antonio Berenguer, Liisa Määttänen, Chris H. Bangma, Gunnar Aus, Arnauld Villers, Xavier Rebillard, Theodorus van der Kwast, Bert G. Blijenberg, Sue M. Moss, Harry J. de Koning, Anssi Auvinen, ERSPC Investigators
Abstract
PSA-based screening reduced the rate of death from prostate cancer by 20% but was associated with a high risk of overdiagnosis. (Current Controlled Trials number, ISRCTN49127736.) ...
|
| |
by Gerald L. Andriole, David D. Crawford, Robert L. Grubb, et al.Saundra S. Buys, David Chia, Timothy R. Church, Mona N. Fouad, Edward P. Gelmann, Paul A. Kvale, Douglas J. Reding, Joel L. Weissfeld, Lance A. Yokochi, Barbara O'Brien, Jonathan D. Clapp, Joshua M. Rathmell, Thomas L. Riley, Richard B. Hayes, Barnett S. Kramer, Grant Izmirlian, Anthony B. Miller, Paul F. Pinsky, Philip C. Prorok, John K. Gohagan, Christine D. Berg, PLCO Project Team
Abstract
After 7 to 10 years of follow-up, the rate of death from prostate cancer was very low and did not differ significantly between the two study groups. (ClinicalTrials.gov number, NCT00002540.) ...
|
| |
JAMA: The Journal of the American Medical Association, Vol. 301, No. 1. (7 January 2009), pp. 39-51, doi:10.1001/jama.2008.864
by Scott M. Lippman, Eric A. Klein, Phyllis J. Goodman, et al.M. Scott Lucia, Ian M. Thompson, Leslie G. Ford, Howard L. Parnes, Lori M. Minasian, J. Michael Gaziano, Jo A. Hartline, J. Kellogg Parsons, James D. Bearden, E. David Crawford, Gary E. Goodman, Jaime Claudio, Eric Winquist, Elise D. Cook, Daniel D. Karp, Philip Walther, Michael M. Lieber, Alan R. Kristal, Amy K. Darke, Kathryn B. Arnold, Patricia A. Ganz, Regina M. Santella, Demetrius Albanes, Philip R. Taylor, Jeffrey L. Probstfield, T. J. Jagpal, John J. Crowley, Frank L. Meyskens, Laurence H. Baker, Charles A. Coltman
posted to no-tag
by cyberwulf
on 2011-02-03 22:47:34
Abstract
Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.Objective To determine whether selenium, vitamin E, or both could prevent prostate cancer and other diseases with little or no toxicity in relatively healthy men.Design, Setting, and Participants A randomized, placebo-controlled trial (Selenium and Vitamin E Cancer Prevention Trial [SELECT]) of 35 533 men from 427 participating sites in the United States, Canada, and Puerto Rico randomly ...
|
| |
posted to no-tag
by cyberwulf
on 2011-01-17 20:06:35
Abstract
Consider a placebo-controlled preventive HIV vaccine efficacy trial. An HIV amino acid sequence is measured from each volunteer who acquires HIV, and these sequences are aligned together with the reference HIV sequence represented in the vaccine. We develop genome scanning methods to identify positions at which the amino acids in infected vaccine recipient sequences either (A) are more divergent from the reference amino acid than the amino acids in infected placebo recipient sequences or (B) have a different frequency distribution than ...
|
| |
(2010)
posted to variable_selection
by cyberwulf
on 2010-11-15 22:45:44
|
| |
JAMA : the journal of the American Medical Association, Vol. 288, No. 2. (10 July 2002), pp. 169-180
by Scott M. Hammer, Florin Vaida, Kara K. Bennett, et al.Mary K. Holohan, Lewis Sheiner, Joseph J. Eron, Lawrence Joseph J. Wheat, Ronald T. Mitsuyasu, Roy M. Gulick, Fred T. Valentine, Judith A. Aberg, Michael D. Rogers, Cheryl N. Karol, Alfred J. Saah, Ronald H. Lewis, Laura J. Bessen, Carol Brosgart, Victor DeGruttola, John W. Mellors, AIDS Clinical Trials Group 398 Study Team
posted to hiv
by cyberwulf
on 2010-07-06 16:34:54
Abstract
Management of antiretroviral treatment failure in patients receiving protease inhibitor (PI)-containing regimens is a therapeutic challenge. To assess whether adding a second PI improves antiviral efficacy of a 4-drug combination in patients with virologic failure while taking a PI-containing regimen. ...
|
| |
In Statistical Thinking in Sports (2008), pp. 241-261
posted to qb
by cyberwulf
on 2010-05-11 22:47:46
|
| |
(09 September 2002)
Abstract
* Emphasizes the latest trends in the field. * Includes a new chapter on evolving methods. * Provides updated or revised material in most of the chapters. ...
|
| |
(22 July 2002)
Abstract
<I>Amstat News</I> asked three review editors to rate their top five favorite books in the September 2003 issue. <I>Categorical Data Analysis</I> was among those chosen. <p> A valuable new edition of a standard reference.<br> "A 'must-have' book for anyone expecting to do research and/or applications in categorical data analysis." <br> -Statistics in Medicine on <I>Categorical Data Analysis</I>, First Edition <p> ...
|
| |
posted to no-tag
by cyberwulf
on 2010-04-13 18:22:54
Abstract
Background: Rosuvastatin and fenofibrate are lipid-regulating agents with different modes of action. Patients with dyslipidemia who have not achieved treatment targets with monotherapy may benefit from the combination of these agents. Objective: The effect of coadministration of rosuvastatin and fenofibrate on the steady-state pharmacokinetics of rosuvastatin and fenofibric acid (the active metabolite of fenofibrate) was assessed in healthy volunteers. Methods: This was an open-label, randomized, 3-way crossover trial consisting of three 7-day treatment periods. Healthy male volunteers received one of the ...
|
| |
posted to qb
by cyberwulf ✚
on 2010-04-11 01:18:39
along with 1 person
plm
Abstract
In many biometrical applications, the count data encountered often contain extra zeros relative to the Poisson distribution. Zero-inflated Poisson regression models are useful for analyzing such data, but parameter estimates may be seriously biased if the nonzero observations are over-dispersed and simultaneously correlated due to the sampling design or the data collection procedure. In this paper, a zero-inflated negative binomial mixed regression model is presented to analyze a set of pancreas disorder length of stay (LOS) data that comprised mainly same-day ...
|
| |
Social Science Research Network Working Paper Series (03 November 2008)
posted to qb
by cyberwulf ✚
on 2010-04-11 01:17:49
along with 1 person
Demeter
Abstract
We present several modifications of the Poisson and negative binomial models for count data to accommodate cases in which the number of zeros in the data exceed what would typically be predicted by either model. The excess zeros can masquerade as overdispersion. We present a new test procedure for distinguishing between zero inflation and overdispersion. We also develop a model for sample selection which is analogous to the Heckman style specification for continuous choice models. An application is presented to a ...
|
| |
Abstract
This is an invited expository article for The American Statistician. It reviews the nonparametric estimation of statistical error, mainly the bias and standard error of an estimator, or the error rate of a prediction rule. The presentation is written at a relaxed mathematical level, omitting most proofs, regularity conditions, and technical details. ...
|
| |
Journal of Quantitative Analysis in Sports, Vol. 1, No. 1. (2005)
posted to football qb
by cyberwulf
on 2010-04-08 19:19:25
Abstract
David Hilbert was a mathematician who in 1900 delivered the most influential speech in the history of mathematics (Hilbert 1902). He outlined 23 major problems to be studied in the next century, while outlining a philosophy for how mathematics should be studied. In the 2000 edition of Baseball Prospectus, Keith Woolner wrote an essay entitled "Baseball's Hilbert Problems."(Kahrl, et al. 2000) Woolner's essay, in the spirit of Hilbert, listed 23 unanswered questions about baseball. If baseball research is now about where ...
|
| |
No. 0711. (June 2007)
Abstract
Seventy quarterbacks were selected during six NFL drafts held 1999-2004. This paper analyzes information available prior to the draft (college, college passing statistics, NFL Combine data) and draft outcomes (overall number picked and signing bonus). Also analyzed for these players are measures of NFL playing opportunity (games played, games started, pass attempts) and measures of productivity (Pro Bowls made, passer rating, DVOA, and DPAR) for up to the first seven years of each drafted player’s NFL career. We find that more ...
|
| |
Journal of strength and conditioning research / National Strength & Conditioning Association, Vol. 17, No. 1. (February 2003), pp. 6-11
posted to qb
by cyberwulf ✚
on 2010-04-08 19:15:00
Abstract
The performance of 326 collegiate football players attending the 2000 National Football League combine was studied to determine whether draft status could be predicted from performance measurements. The combine measured height and weight along with 9 performance tests: 225-lb bench press test, 10-yd dash, 20-yd dash, 40-yd dash, 20-yd proagility shuttle, 60-yd shuttle, 3-cone drill, broad jump, and vertical jump. Prediction equations were generated for 7 position categories with varying degrees of accuracy-running backs (RBs), r(2) = 1.00; wide receivers (WRs), ...
|
| |
(3 April 2010)
posted to qb
by cyberwulf ✚
on 2010-04-08 19:13:01
Abstract
A question of increasing interest to researchers in a variety of fields is whether the biases found in judgment and decision making research remain present in contexts in which experienced participants face strong economic incentives. To investigate this question, we analyze the decision making of National Football League teams during their annual player draft. This is a domain in which monetary stakes are exceedingly high and the opportunities for learning are rich. It is also a domain in which multiple psychological ...
|
| |
(23 March 2006)
posted to qb
by cyberwulf ✚
on 2010-04-08 19:08:12
|
| |
Journal of Labor Economics, Vol. 21, No. 4. (1 October 2003), pp. 857-886, doi:10.1086/377025
posted to qb
by cyberwulf ✚
on 2010-04-08 19:05:17
Abstract
doi: 10.1086/377025 In this article, we analyze the impact of uncertainty on the hiring process. We show the connection between models of statistical discrimination where uncertainty can work against groups that have less reliable indicators of future productivity and models of option value where uncertainty about future productivity can be beneficial for these groups. These models generate hypotheses about the relationship between ex ante hiring patterns and ex post productivity. This is applied to the market for NFL football players. We ...
|
| |
The New Yorker (15 December 2008)
posted to no-tag
by cyberwulf ✚
on 2010-04-08 19:03:27
|
| |
posted to qb
by cyberwulf ✚
on 2010-04-08 19:00:05
Abstract
Abstract The reverse order college draft gives the worst teams in the National Football League (NFL) the opportunity to hire the best amateur talent. For it to work effectively, teams must be able to identify the “best” talent. Our study of NFL quarterbacks highlights problems with the draft process. We find only a weak correlation between teams’ evaluations on draft day and subsequent quarterback performance in the NFL. Moreover, many of the factors that enhance a quarterback’s draft position are unrelated to ...
|
| |
(12 July 2007)
posted to qb
by cyberwulf
on 2010-04-08 18:56:38
Abstract
Investigating a wide range of international team and individual sports, the book considers the ability to make predictions, define trends, and measure any number of influences. It is full of interesting and useful examples for those teaching introductory statistics. Although the articles are aimed at general readers, the serious researcher in sports statistics will also find the articles of value and highly useful as starting points for further research. ...
|
| |
posted to no-tag
by cyberwulf
on 2010-02-15 18:50:27
Abstract
Since the seminal papers by Huber in the 1960s, M-estimation methods (also known as estimating equation methods) have been increasingly important for asymptotic analysis and approximate inference. This article illustrates the breadth and generality of the M-estimation approach, thereby facilitating its use in practice and in the classroom as a unifying approach to the study of large-sample inference. ...
|
| |
posted to no-tag
by cyberwulf
on 2010-02-15 18:48:08
Abstract
Moment methods for analyzing repeated binary responses have been proposed by Liang and Zeger (1986, Biometrika 73, 13-22), and extended by Prentice (1988, Biometrics 44, 1033-1048). In their generalized estimating equations (GEE), both Liang and Zeger (1986) and Prentice (1988) estimate the parameters associated with the expected value of an individual's vector of binary responses as well as the correlations between pairs of binary responses. In this paper, we discuss one-step estimators, i.e., estimators obtained from one step of the generalized ...
|
| |
Abstract
BACKGROUND: Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV). METHODS: We randomly assigned persons infected with HIV who had a CD4+ cell count of more than 350 per cubic millimeter to the continuous use of antiretroviral therapy (the viral suppression group) or the episodic use of antiretroviral therapy (the drug conservation group). Episodic use involved the deferral of ...
|
Search
