Electrophysiology in the age of light Export

@article{ScanzianiHaeusser09, abstract = {Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes. Together with new forms of microscopy, these probes allow us to measure and control neuronal signals with spatial resolution and genetic specificity that already greatly surpass those of electrophysiology. We predict that the photon will progressively replace the electron for probing neuronal function, particularly for targeted stimulation and silencing of neuronal populations. Although electrophysiological characterization of channels, cells and neural circuits will remain necessary, new combinations of electrophysiology and imaging should lead to transformational discoveries in neuroscience.}, author = {Scanziani, Massimo and Hausser, Michael}, citeulike-article-id = {5942072}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08540}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08540}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19829373}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19829373}, day = {14}, doi = {10.1038/nature08540}, issn = {0028-0836}, journal = {Nature}, keywords = {eeg, methodology, optics, single-cell-recording}, month = {October}, number = {7266}, pages = {930--939}, posted-at = {2009-10-15 10:05:51}, priority = {2}, publisher = {Nature Publishing Group}, title = {Electrophysiology in the age of light}, url = {http://dx.doi.org/10.1038/nature08540}, volume = {461}, year = {2009} }

TY - JOUR ID - ScanzianiHaeusser09 L3 - citeulike-article-id:5942072 N2 - Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes. Together with new forms of microscopy, these probes allow us to measure and control neuronal signals with spatial resolution and genetic specificity that already greatly surpass those of electrophysiology. We predict that the photon will progressively replace the electron for probing neuronal function, particularly for targeted stimulation and silencing of neuronal populations. Although electrophysiological characterization of channels, cells and neural circuits will remain necessary, new combinations of electrophysiology and imaging should lead to transformational discoveries in neuroscience. IS - 7266 JF - Nature SN - 0028-0836 EP - 939 TI - Electrophysiology in the age of light PB - Nature Publishing Group VL - 461 SP - 930 KW - eeg KW - methodology KW - optics KW - single-cell-recording AU - Scanziani, Massimo AU - Hausser, Michael PY - 2009/10/14/ UR - http://dx.doi.org/10.1038/nature08540 ER -