Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Export

@article{citeulike:1849738, abstract = {We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases.}, address = {Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.}, author = {{} and Burton, Paul R R. and Clayton, David G G. and Cardon, Lon R R. and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P P. and McCarthy, Mark I I. and Ouwehand, Willem H H. and Samani, Nilesh J J. and Todd, John A A. and Donnelly Chair, Peter and {} and Barrett, Jeffrey C C. and Burton, Paul R R. and Davison, Dan and Donnelly, Peter and Easton, Doug and Evans, David M M. and Leung, Hin-Tak T. and Marchini, Jonathan L L. and Morris, Andrew P P. and Spencer, Chris Ca C. and Tobin, Martin D D. and Cardon, Lon R R. and Clayton, David G G. and {} and Attwood, Antony P P. and Boorman, James P P. and Cant, Barbara and Everson, Ursula and Hussey, Judith M M. and Jolley, Jennifer D D. and Knight, Alexandra S S. and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V V. and Stevens, Helen E E. and Taylor, Niall C C. and Walters, Graham R R. and Walker, Neil M M. and Watkins, Nicholas A A. and Winzer, Thilo and Todd, John A A. and Ouwehand, Willem H H. and {} and Jones, Richard W W. and McArdle, Wendy L L. and Ring, Susan M M. and Strachan, David P P. and Pembrey, Marcus and {} and Breen, Gerome and Clair, David St S. and {} and Caesar, Sian and Gordon-Smith, Katharine and Jones, Lisa and {} and Fraser, Christine and Green, Elaine K K. and Grozeva, Detelina and Hamshere, Marian L L. and Holmans, Peter A A. and Jones, Ian R R. and Kirov, George and Moskivina, Valentina and Nikolov, Ivan and O'Donovan, Michael C C. and Owen, Michael J J. and Craddock, Nick and {} and Collier, David A A. and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and {} and Young, Allan H H. and Ferrier, I Nicol N. and {} and Ball, Stephen G G. and Balmforth, Anthony J J. and Barrett, Jennifer H H. and Bishop, Timothy D D. and Iles, Mark M M. and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S S. and {} and Braund, Peter S S. and Burton, Paul R R. and Dixon, Richard J J. and Mangino, Massimo and Stevens, Suzanne and Tobin, Martin D D. and Thompson, John R R. and Samani, Nilesh J J. and {} and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and {} and Drummond, Hazel and Lees, Charles W W. and Nimmo, Elaine R R. and Satsangi, Jack and {} and Fisher, Sheila A A. and Forbes, Alastair and Lewis, Cathryn M M. and Onnie, Clive M M. and Prescott, Natalie J J. and Sanderson, Jeremy and Matthew, Christopher G G. and {} and Barbour, Jamie and Mohiuddin, M Khalid K. and Todhunter, Catherine E E. and Mansfield, John C C. and {} and Ahmad, Tariq and Cummings, Fraser R R. and Jewell, Derek P P. and {} and Webster, John and {} and Brown, Morris J J. and Clayton, David G G. and {} and Lathrop, Mark G G. and {} and Connell, John and Dominiczak, Anna and {} and Samani, Nilesh J J. and {} and Marcano, Carolina A Braga A. and Burke, Beverley and Dobson, Richard and Gungadoo, Johannie and Lee, Kate L L. and Munroe, Patricia B B. and Newhouse, Stephen J J. and Onipinla, Abiodun and Wallace, Chris and Xue, Mingzhan and Caulfield, Mark and {} and Farrall, Martin and {} and Barton, Anne and {} and Bruce, Ian N N. and Donovan, Hannah and Eyre, Steve and Gilbert, Paul D D. and Hilder, Samantha L L. and Hinks, Anne M M. and John, Sally L L. and Potter, Catherine and Silman, Alan J J. and Symmons, Deborah Pm P. and Thomson, Wendy and Worthington, Jane and {} and Clayton, David G G. and Dunger, David B B. and Nutland, Sarah and Stevens, Helen E E. and Walker, Neil M M. and Widmer, Barry and Todd, John A A. and {} and Frayling, Timothy M M. and Freathy, Rachel M M. and Lango, Hana and Perry, John R B R. and Shields, Beverley M M. and Weedon, Michael N N. and Hattersley, Andrew T T. and {} and Hitman, Graham A A. and {} and Walker, Mark and {} and Elliott, Kate S S. and Groves, Christopher J J. and Lindgren, Cecilia M M. and Rayner, Nigel W W. and Timpson, Nicolas J J. and Zeggini, Eleftheria and McCarthy, Mark I I. and {} and Newport, Melanie and Sirugo, Giorgio and {} and Lyons, Emily and Vannberg, Fredrik and Hill, Adrian V S V. and {} and Bradbury, Linda A A. and Farrar, Claire and Pointon, Jennifer J J. and Wordsworth, Paul and Brown, Matthew A A. and {} and Franklyn, Jayne A A. and Heward, Joanne M M. and Simmonds, Matthew J J. and Gough, Stephen Cl C. and {} and Seal, Sheila and {} and Stratton, Michael R R. and Rahman, Nazneen and {} and Ban, Maria and Goris, An and Sawcer, Stephen J J. and Compston, Alastair and {} and Conway, David and Jallow, Muminatou and Newport, Melanie and Sirugo, Giorgio and {} and Rockett, Kirk A A. and Kwiatkowski, Dominic P P. and {} and Bumpstead, Suzannah J J. and Chaney, Amy and Downes, Kate and Ghori, Mohammed Jr J. and Gwilliam, Rhian and Hunt, Sarah E E. and Inouye, Michael and Keniry, Andrew and King, Emma and McGinnis, Ralph and Potter, Simon and Ravindrarajah, Rathi and Whittaker, Pamela and Widden, Claire and Withers, David and Deloukas, Panos and {} and Leung, Hin-Tak T. and Nutland, Sarah and Stevens, Helen E E. and Walker, Neil M M. and Todd, John A A. and {} and Easton, Doug and Clayton, David G G. and {} and Burton, Paul R R. and Tobin, Martin D D. and {} and Barrett, Jeffrey C C. and Evans, David M M. and Morris, Andrew P P. and Cardon, Lon R R. and {} and Cardin, Niall J J. and Davison, Dan and Ferreira, Teresa and Pereira-Gale, Joanne and Hallgrimsd\'{o}ttir, Ingeleif B B. and Howie, Bryan N N. and Marchini, Jonathan L L. and Spencer, Chris Ca C. and Su, Zhan and Teo, Yik Ying Y. and Vukcevic, Damjan and Donnelly, Peter and {} and Bentley, David and Brown, Matthew A A. and Cardon, Lon R R. and Caulfield, Mark and Clayton, David G G. and Compston, Alastair and Craddock, Nick and Deloukas, Panos and Donnelly, Peter and Farrall, Martin and Gough, Stephen Cl C. and Hall, Alistair S S. and Hattersley, Andrew T T. and Hill, Adrian V S V. and Kwiatkowski, Dominic P P. and Matthew, Christopher G G. and McCarthy, Mark I I. and Ouwehand, Willem H H. and Parkes, Miles and Pembrey, Marcus and Rahman, Nazneen and Samani, Nilesh J J. and Stratton, Michael R R. and Todd, John A A. and Worthington, Jane and {} and Mitchell, Sarah L L. and Newby, Paul R R. and Brand, Oliver J J. and Carr-Smith, Jackie and Pearce, Simon H S H. and Gough, Stephen C L C. and {} and McGinnis, R and Keniry, A and Deloukas, P and {} and Reveille, John D D. and Zhou, Xiaodong and Bradbury, Linda A A. and Sims, Anne-Marie M. and Dowling, Alison and Taylor, Jacqueline and Doan, Tracy and Cardon, Lon R R. and Davis, John C C. and Pointon, Jennifer J J. and Savage, Laurie and Ward, Michael M M. and Learch, Thomas L L. and Weisman, Michael H H. and Wordsworth, Paul and Brown, Matthew A A.}, citeulike-article-id = {1849738}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.2007.17}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.2007.17}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17952073}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17952073}, doi = {10.1038/ng.2007.17}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {assoc, humgen, nssnps}, month = {November}, number = {11}, pages = {1329--1337}, posted-at = {2009-03-31 22:10:09}, priority = {2}, title = {Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.}, url = {http://dx.doi.org/10.1038/ng.2007.17}, volume = {39}, year = {2007} }

TY - JOUR ID - citeulike:1849738 L3 - citeulike-article-id:1849738 N2 - We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. IS - 11 JF - Nat Genet SN - 1061-4036 AD - Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK. EP - 1337 TI - Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. VL - 39 SP - 1329 KW - assoc KW - humgen KW - nssnps AU - Burton, Paul R AU - Clayton, David G AU - Cardon, Lon R AU - Craddock, Nick AU - Deloukas, Panos AU - Duncanson, Audrey AU - Kwiatkowski, Dominic P AU - McCarthy, Mark I AU - Ouwehand, Willem H AU - Samani, Nilesh J AU - Todd, John A AU - Donnelly Chair, Peter AU - Barrett, Jeffrey C AU - Burton, Paul R AU - Davison, Dan AU - Donnelly, Peter AU - Easton, Doug AU - Evans, David M AU - Leung, Hin-Tak AU - Marchini, Jonathan L AU - Morris, Andrew P AU - Spencer, Chris Ca AU - Tobin, Martin D AU - Cardon, Lon R AU - Clayton, David G AU - Attwood, Antony P AU - Boorman, James P AU - Cant, Barbara AU - Everson, Ursula AU - Hussey, Judith M AU - Jolley, Jennifer D AU - Knight, Alexandra S AU - Koch, Kerstin AU - Meech, Elizabeth AU - Nutland, Sarah AU - Prowse, Christopher V AU - Stevens, Helen E AU - Taylor, Niall C AU - Walters, Graham R AU - Walker, Neil M AU - Watkins, Nicholas A AU - Winzer, Thilo AU - Todd, John A AU - Ouwehand, Willem H AU - Jones, Richard W AU - McArdle, Wendy L AU - Ring, Susan M AU - Strachan, David P AU - Pembrey, Marcus AU - Breen, Gerome AU - Clair, David St AU - Caesar, Sian AU - Gordon-Smith, Katharine AU - Jones, Lisa AU - Fraser, Christine AU - Green, Elaine K AU - Grozeva, Detelina AU - Hamshere, Marian L AU - Holmans, Peter A AU - Jones, Ian R AU - Kirov, George AU - Moskivina, Valentina AU - Nikolov, Ivan AU - O'Donovan, Michael C AU - Owen, Michael J AU - Craddock, Nick AU - Collier, David A AU - Elkin, Amanda AU - Farmer, Anne AU - Williamson, Richard AU - McGuffin, Peter AU - Young, Allan H AU - Ferrier, I Nicol AU - Ball, Stephen G AU - Balmforth, Anthony J AU - Barrett, Jennifer H AU - Bishop, Timothy D AU - Iles, Mark M AU - Maqbool, Azhar AU - Yuldasheva, Nadira AU - Hall, Alistair S AU - Braund, Peter S AU - Burton, Paul R AU - Dixon, Richard J AU - Mangino, Massimo AU - Stevens, Suzanne AU - Tobin, Martin D AU - Thompson, John R AU - Samani, Nilesh J AU - Bredin, Francesca AU - Tremelling, Mark AU - Parkes, Miles AU - Drummond, Hazel AU - Lees, Charles W AU - Nimmo, Elaine R AU - Satsangi, Jack AU - Fisher, Sheila A AU - Forbes, Alastair AU - Lewis, Cathryn M AU - Onnie, Clive M AU - Prescott, Natalie J AU - Sanderson, Jeremy AU - Matthew, Christopher G AU - Barbour, Jamie AU - Mohiuddin, M Khalid AU - Todhunter, Catherine E AU - Mansfield, John C AU - Ahmad, Tariq AU - Cummings, Fraser R AU - Jewell, Derek P AU - Webster, John AU - Brown, Morris J AU - Clayton, David G AU - Lathrop, Mark G AU - Connell, John AU - Dominiczak, Anna AU - Samani, Nilesh J AU - Marcano, Carolina A Braga AU - Burke, Beverley AU - Dobson, Richard AU - Gungadoo, Johannie AU - Lee, Kate L AU - Munroe, Patricia B AU - Newhouse, Stephen J AU - Onipinla, Abiodun AU - Wallace, Chris AU - Xue, Mingzhan AU - Caulfield, Mark AU - Farrall, Martin AU - Barton, Anne AU - Bruce, Ian N AU - Donovan, Hannah AU - Eyre, Steve AU - Gilbert, Paul D AU - Hilder, Samantha L AU - Hinks, Anne M AU - John, Sally L AU - Potter, Catherine AU - Silman, Alan J AU - Symmons, Deborah Pm AU - Thomson, Wendy AU - Worthington, Jane AU - Clayton, David G AU - Dunger, David B AU - Nutland, Sarah AU - Stevens, Helen E AU - Walker, Neil M AU - Widmer, Barry AU - Todd, John A AU - Frayling, Timothy M AU - Freathy, Rachel M AU - Lango, Hana AU - Perry, John R B AU - Shields, Beverley M AU - Weedon, Michael N AU - Hattersley, Andrew T AU - Hitman, Graham A AU - Walker, Mark AU - Elliott, Kate S AU - Groves, Christopher J AU - Lindgren, Cecilia M AU - Rayner, Nigel W AU - Timpson, Nicolas J AU - Zeggini, Eleftheria AU - McCarthy, Mark I AU - Newport, Melanie AU - Sirugo, Giorgio AU - Lyons, Emily AU - Vannberg, Fredrik AU - Hill, Adrian V S AU - Bradbury, Linda A AU - Farrar, Claire AU - Pointon, Jennifer J AU - Wordsworth, Paul AU - Brown, Matthew A AU - Franklyn, Jayne A AU - Heward, Joanne M AU - Simmonds, Matthew J AU - Gough, Stephen Cl AU - Seal, Sheila AU - Stratton, Michael R AU - Rahman, Nazneen AU - Ban, Maria AU - Goris, An AU - Sawcer, Stephen J AU - Compston, Alastair AU - Conway, David AU - Jallow, Muminatou AU - Newport, Melanie AU - Sirugo, Giorgio AU - Rockett, Kirk A AU - Kwiatkowski, Dominic P AU - Bumpstead, Suzannah J AU - Chaney, Amy AU - Downes, Kate AU - Ghori, Mohammed Jr AU - Gwilliam, Rhian AU - Hunt, Sarah E AU - Inouye, Michael AU - Keniry, Andrew AU - King, Emma AU - McGinnis, Ralph AU - Potter, Simon AU - Ravindrarajah, Rathi AU - Whittaker, Pamela AU - Widden, Claire AU - Withers, David AU - Deloukas, Panos AU - Leung, Hin-Tak AU - Nutland, Sarah AU - Stevens, Helen E AU - Walker, Neil M AU - Todd, John A AU - Easton, Doug AU - Clayton, David G AU - Burton, Paul R AU - Tobin, Martin D AU - Barrett, Jeffrey C AU - Evans, David M AU - Morris, Andrew P AU - Cardon, Lon R AU - Cardin, Niall J AU - Davison, Dan AU - Ferreira, Teresa AU - Pereira-Gale, Joanne AU - Hallgrimsdóttir, Ingeleif B AU - Howie, Bryan N AU - Marchini, Jonathan L AU - Spencer, Chris Ca AU - Su, Zhan AU - Teo, Yik Ying AU - Vukcevic, Damjan AU - Donnelly, Peter AU - Bentley, David AU - Brown, Matthew A AU - Cardon, Lon R AU - Caulfield, Mark AU - Clayton, David G AU - Compston, Alastair AU - Craddock, Nick AU - Deloukas, Panos AU - Donnelly, Peter AU - Farrall, Martin AU - Gough, Stephen Cl AU - Hall, Alistair S AU - Hattersley, Andrew T AU - Hill, Adrian V S AU - Kwiatkowski, Dominic P AU - Matthew, Christopher G AU - McCarthy, Mark I AU - Ouwehand, Willem H AU - Parkes, Miles AU - Pembrey, Marcus AU - Rahman, Nazneen AU - Samani, Nilesh J AU - Stratton, Michael R AU - Todd, John A AU - Worthington, Jane AU - Mitchell, Sarah L AU - Newby, Paul R AU - Brand, Oliver J AU - Carr-Smith, Jackie AU - Pearce, Simon H S AU - Gough, Stephen C L AU - McGinnis, R AU - Keniry, A AU - Deloukas, P AU - Reveille, John D AU - Zhou, Xiaodong AU - Bradbury, Linda A AU - Sims, Anne-Marie AU - Dowling, Alison AU - Taylor, Jacqueline AU - Doan, Tracy AU - Cardon, Lon R AU - Davis, John C AU - Pointon, Jennifer J AU - Savage, Laurie AU - Ward, Michael M AU - Learch, Thomas L AU - Weisman, Michael H AU - Wordsworth, Paul AU - Brown, Matthew A PY - 2007/11// UR - http://dx.doi.org/10.1038/ng.2007.17 ER -