A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. Export

@article{citeulike:5041060, abstract = {Telomere length is a predictor for a number of common age-related diseases and is a heritable trait. To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314,075 SNPs and validated the results in a second cohort (n for both cohorts combined= 2,790). We identified two novel associated variants (rs2162440; p-value=2.6x10(-6) and rs7235755; p-value=5.5x10(-6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. These results provide new insights into the pathways regulating telomere homeostasis in humans.}, author = {Mangino, Massimo and Richards, J. Brent and Soranzo, Nicole and Zhai, Guangju and Aviv, Abraham and Valdes, Ana M. and Samani, Nilesh J. and Deloukas, Panos and Spector, Tim D.}, citeulike-article-id = {5041060}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/jmg.2008.064956}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19359265}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19359265}, day = {24}, doi = {10.1136/jmg.2008.064956}, issn = {1468-6244}, journal = {Journal of medical genetics}, keywords = {aging, gwas, humgen, qtl}, month = {April}, posted-at = {2009-07-02 10:47:01}, priority = {2}, title = {A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.}, url = {http://dx.doi.org/10.1136/jmg.2008.064956}, year = {2009} }

TY - JOUR ID - citeulike:5041060 L3 - citeulike-article-id:5041060 N2 - Telomere length is a predictor for a number of common age-related diseases and is a heritable trait. To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314,075 SNPs and validated the results in a second cohort (n for both cohorts combined= 2,790). We identified two novel associated variants (rs2162440; p-value=2.6x10(-6) and rs7235755; p-value=5.5x10(-6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast. These results provide new insights into the pathways regulating telomere homeostasis in humans. JF - Journal of medical genetics SN - 1468-6244 TI - A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length. KW - aging KW - gwas KW - humgen KW - qtl AU - Mangino, Massimo AU - Richards, Brent AU - Soranzo, Nicole AU - Zhai, Guangju AU - Aviv, Abraham AU - Valdes, Ana AU - Samani, Nilesh AU - Deloukas, Panos AU - Spector, Tim PY - 2009/04/24/ UR - http://dx.doi.org/10.1136/jmg.2008.064956 ER -