Common disorders are quantitative traits Export

@article{citeulike:6064773, abstract = {After drifting apart for 100 years, the two worlds of genetics — quantitative genetics and molecular genetics — are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits — including the low and high ends of normal distributions — could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.}, author = {Plomin, Robert and Haworth, Claire M. A. and Davis, Oliver S. P.}, citeulike-article-id = {6064773}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2670}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2670}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19859063}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19859063}, day = {27}, doi = {10.1038/nrg2670}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {assoc, genomics, gwas, highly, humgen, qtl}, month = {October}, number = {12}, pages = {872--878}, posted-at = {2009-11-04 22:47:51}, priority = {2}, publisher = {Nature Publishing Group}, title = {Common disorders are quantitative traits}, url = {http://dx.doi.org/10.1038/nrg2670}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:6064773 L3 - citeulike-article-id:6064773 N2 - After drifting apart for 100 years, the two worlds of genetics — quantitative genetics and molecular genetics — are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits — including the low and high ends of normal distributions — could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits. IS - 12 JF - Nature Reviews Genetics SN - 1471-0056 EP - 878 TI - Common disorders are quantitative traits PB - Nature Publishing Group VL - 10 SP - 872 KW - assoc KW - genomics KW - gwas KW - highly KW - humgen KW - qtl AU - Plomin, Robert AU - Haworth, Claire AU - Davis, Oliver PY - 2009/10/27/ UR - http://dx.doi.org/10.1038/nrg2670 ER -