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Mouse ooplasm confers context-specific reprogramming capacity

by: Michelle M. Chan, Zachary D. Smith, Dieter Egli, Aviv Regev, Alexander Meissner
Nature Genetics, Vol. 44, No. 9. (19 August 2012), pp. 978-980, doi:10.1038/ng.2382  Key: citeulike:11183766

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Abstract

Alex Meissner and colleagues report base pairresolution methylation maps from donor fibroblasts and nuclear transferreconstructed mouse embryos. They compare methylation profiles to that present during normal fertilization and find that specific promoters and repeat elements exhibit differential dynamics.


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