EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis. Export

@article{citeulike:1246062, abstract = {The relationship between EBV infection and sensitivity to death receptor (DR)-induced apoptosis is poorly understood. Using EBV- and EBV+ BJAB cells, we provide the first evidence that EBV can protect latently infected B cell lymphomas from apoptosis triggered through Fas or TRAIL receptors. Caspase 8 activation was impaired and cellular FLIP recruitment was enriched in death-inducing signaling complexes formed in EBV-infected BJAB cells relative to parent BJAB cells. Furthermore, latent membrane protein 1 expression alone could reduce caspase activation and confer partial resistance to DR apoptosis in BJAB cells. This protective effect was dependent on C-terminal activating region 2-driven NF-kappaB activation, which in turn up-regulated cellular FLIP expression in latent membrane protein 1+ BJAB cells. Thus, the ability of latent EBV to block DR apoptosis may help to ensure the survival of host cells during B cell differentiation, and contribute to the development of B cell lymphomas, especially in immunocompromised individuals.}, address = {Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.}, author = {Snow, A. L. and Lambert, S. L. and Natkunam, Y. and Esquivel, C. O. and Krams, S. M. and Martinez, O. M.}, citeulike-article-id = {1246062}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/16920969}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=16920969}, comment = {One of the original papers given by LC 4-23-07}, day = {1}, issn = {0022-1767}, journal = {J Immunol}, keywords = {by, given, lc, of, one, original, papers, the}, month = {September}, number = {5}, pages = {3283--3293}, posted-at = {2007-04-23 21:58:11}, priority = {0}, title = {EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16920969}, volume = {177}, year = {2006} }

TY - JOUR ID - citeulike:1246062 L3 - citeulike-article-id:1246062 N2 - The relationship between EBV infection and sensitivity to death receptor (DR)-induced apoptosis is poorly understood. Using EBV- and EBV+ BJAB cells, we provide the first evidence that EBV can protect latently infected B cell lymphomas from apoptosis triggered through Fas or TRAIL receptors. Caspase 8 activation was impaired and cellular FLIP recruitment was enriched in death-inducing signaling complexes formed in EBV-infected BJAB cells relative to parent BJAB cells. Furthermore, latent membrane protein 1 expression alone could reduce caspase activation and confer partial resistance to DR apoptosis in BJAB cells. This protective effect was dependent on C-terminal activating region 2-driven NF-kappaB activation, which in turn up-regulated cellular FLIP expression in latent membrane protein 1+ BJAB cells. Thus, the ability of latent EBV to block DR apoptosis may help to ensure the survival of host cells during B cell differentiation, and contribute to the development of B cell lymphomas, especially in immunocompromised individuals. IS - 5 JF - J Immunol SN - 0022-1767 AD - Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. EP - 3293 TI - EBV can protect latently infected B cell lymphomas from death receptor-induced apoptosis. VL - 177 SP - 3283 KW - by KW - given KW - lc KW - of KW - one KW - original KW - papers KW - the N1 - One of the original papers given by LC 4-23-07 AU - Snow, AL AU - Lambert, SL AU - Natkunam, Y AU - Esquivel, CO AU - Krams, SM AU - Martinez, OM PY - 2006/09/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/16920969 ER -