Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis Export

@article{citeulike:2459071, abstract = {Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection. 10.1128/MMBR.67.2.175-212.2003}, author = {Dourmishev, Lyubomir A. and Dourmishev, Assen L. and Palmeri, Diana and Schwartz, Robert A. and Lukac, David M.}, citeulike-article-id = {2459071}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/MMBR.67.2.175-212.2003}, citeulike-linkout-1 = {http://mmbr.asm.org/cgi/content/abstract/67/2/175}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12794189}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12794189}, day = {1}, doi = {10.1128/MMBR.67.2.175-212.2003}, journal = {Microbiol. Mol. Biol. Rev.}, keywords = {mhv68}, month = {June}, number = {2}, pages = {175--212}, posted-at = {2008-03-03 02:17:52}, priority = {5}, title = {Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis}, url = {http://dx.doi.org/10.1128/MMBR.67.2.175-212.2003}, volume = {67}, year = {2003} }

TY - JOUR ID - citeulike:2459071 L3 - citeulike-article-id:2459071 N2 - Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection. 10.1128/MMBR.67.2.175-212.2003 IS - 2 JF - Microbiol. Mol. Biol. Rev. EP - 212 TI - Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis VL - 67 SP - 175 KW - mhv68 AU - Dourmishev, Lyubomir AU - Dourmishev, Assen AU - Palmeri, Diana AU - Schwartz, Robert AU - Lukac, David PY - 2003/06/01/ UR - http://dx.doi.org/10.1128/MMBR.67.2.175-212.2003 ER -